Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1997-12-24
1999-11-16
Raymond, Richard L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514211, 5142228, 5142302, 540468, 540471, 540546, 540548, 540555, 540559, 544 14, 544 32, 544 73, 544 95, A61K 31535, C07D49804, C07D49814
Patent
active
059858710
ABSTRACT:
Compounds having a certain benzoxazine ring system and their precursors are disclosed which are useful for enhancing synaptic responses mediated by AMPA receptors. Also disclosed are methods for preparing such compounds, and methods for their use in treating subjects suffering from impaired nervous or intellectual functioning due to deficiencies in the number of excitatory synapses or in the number of AMPA receptors. The invention compounds can also be used for the treatment of non-impaired subjects for enhancing performance in sensory-motor and cognitive tasks which depend on brain networks utilizing AMPA receptors and for improving memory encoding.
REFERENCES:
patent: 5650409 (1997-07-01), Rogers et al.
patent: 5736543 (1998-04-01), Rogers et al.
Kapor et al., Chemical Abstracts, vol. 122, abstract 119629, 1995.
Ziegler et al., Chemical Abstracts, vol. 70, abstract 3979, 1969.
Marrs Christopher
Rogers Gary A.
Cortex Pharmaceuticals, Inc.
Powers Vincent M.
Raymond Richard L.
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