Benzoxazine and benzoxazepine carboxamide 5-HT.sub.3 antagonists

Details Benzoxazine and benzoxazepine carboxamide 5-HT.sub.3 antagonists Benzoxazine and benzoxazepine carboxamide 5-HT.sub.3 antagonists

1989-09-26

1990-06-19

Shah, Mukund J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

544105, A61K 3155, A61K 31535, C07D26536, C07D26714

Patent

active

049355112

ABSTRACT:
This invention relates to benzoxazine and benzoxazepine carboxamide compounds which exhibit 5-HT.sub.3 antagonist properties including CNS, anti-emetic and gastric prokinetic activity and which are void of any significant D.sub.2 receptor binding affinity. This invention also relates to pharmaceutical compositions and methods for the treatment of gastrointestinal and mental disorders using said compounds.

REFERENCES:
patent: 4857517 (1989-08-01), Youssefyeh et al.
patent: 4859683 (1989-08-01), Youssefyeh et al.
Chem. Abstract, vol. 109:160437v (1988), Kaneko.

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