Benzotriazole derivatives and fluorescence-emitting reagents the

Details Benzotriazole derivatives and fluorescence-emitting reagents the Benzotriazole derivatives and fluorescence-emitting reagents the

1990-11-20

1992-07-21

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548261, 544132, 544366, 436800, 546199, C07D24918

Patent

active

051324296

ABSTRACT:
##STR1## The invention relates to compounds represented by formula (I) and their salts: wherein R.sup.1 represents hydrogen, lower alkyl, halogen, cyano, or lower alkyloxycarbonyl, R.sup.2 and R.sup.3 each represents hydrogen, lower alkyl, C.sub.3 -C.sub.7 cycloalkyl, or aryl, or taken together may form piperazino or morpholino together with the adjacent nitrogen atom. These compounds scarcely emit fluorescence when present alone in an aqueous solution but, in the presence of a protein such as .alpha..sub.1 -AG, they bind to the protein to emit strong fluorescence, thus being suitable reagents for determining proteins existing in a minute amount in blood, particularly .alpha..sub.1 -AG.

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Chem. Abstr. vol. 112, Entry 178992u (1990) abstracts WO8912044.
Chem Abstr. vol. 112 Entry 32813q (1990).
Narita et al. Chem. Abstr. vol. 111 entry 32998h (1989).

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