Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1985-10-28
1987-10-27
Bond, Robert T.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
548252, 548253, 548254, C07D40504, C07D40512, C07D40904, A61K 3141
Patent
active
047030534
ABSTRACT:
Novel benzothiophene and benzofuran derivatives having antiallergic activity are described as well as a method of manufacture, pharmaceutical compositions, and methods of use therefor. The disclosure describes the use of derivatives for prevention of the release of mediators including histamine and leukotrienes from basophils and mast cells, and prevent respiratory burst in neutrophils providing activity useful in cardiovascular disorders as well as in antiinflammatory, psoriasis, and antimigraine treatment.
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B. Samuelsson, "Leukotrienes: Mediators of Immediate Hypersensitivity Reactions and Inflamation," Science, vol. 220, p. 568 (1983).
P. J. Piper, "Leukatrienes:" Trends in Pharmacological Sciences, pp. 75 & 77 (1983).
J. L. Romson, et al; "Reduction of the Extent of Ischemic Myocardial Injury by Neutropil Depletion in the Dog," Circulation, vol. 67, p. 1016 (1983).
Cetenko Wiaczeslaw A.
Connor David T.
Johnson Elizabeth A.
Unangst Paul C.
Bond Robert T.
Springer D. B.
Thierstein Joan
Warner-Lambert & Company
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