Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2011-01-18
2011-01-18
Chung, Susannah (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S422000, C548S525000, C548S527000, C549S051000, C549S058000
Reexamination Certificate
active
07872024
ABSTRACT:
The present invention relates to a novel class of hydroxamic acid derivatives carbamate, urea, amide and sulfonamide substitutions. The hydroxamic acid compounds can be used to treat cancer. The hydroxamic acid compounds can also inhibit histone deacetylase and are suitable for use in selectively inducing terminal differentiation, and arresting cell growth and/or apoptosis of neoplastic cells, thereby inhibiting proliferation of such cells. Thus, the compounds of the present invention are useful in treating a patient having a tumor characterized by proliferation of neoplastic cells. The compounds of the invention are also useful in the prevention and treatment of TRX-mediated diseases, such as autoimmune, allergic and inflammatory diseases, and in the prevention and/or treatment of diseases of the central nervous system (CNS), such as neurodegenerative diseases. The present invention further provides pharmaceutical compositions comprising the hydroxamic acid derivatives and safe dosing regimens of these pharmaceutical compositions, which are easy to follow, and which result in a therapeutically effective amount of the hydroxamic acid derivatives in vivo.
REFERENCES:
patent: 5244893 (1993-09-01), Elbe et al.
patent: 5369108 (1994-11-01), Breslow et al.
patent: 5700811 (1997-12-01), Breslow et al.
patent: 5932616 (1999-08-01), Breslow et al.
patent: 6087367 (2000-07-01), Breslow et al.
patent: 6511990 (2003-01-01), Breslow et al.
patent: 6777425 (2004-08-01), Burli et al.
patent: 7772238 (2010-08-01), Hubbs et al.
patent: 2003/0139404 (2003-07-01), Haag et al.
patent: 2004/0106599 (2004-06-01), Delorme et al.
patent: 2004/0142953 (2004-07-01), Delorme et al.
patent: 2004/0157841 (2004-08-01), Fertig et al.
patent: 2004/0192744 (2004-09-01), Haag et al.
patent: 2005/0288282 (2005-12-01), Delorme et al.
patent: 2007/0213392 (2007-09-01), Miller et al.
patent: 2009/0069391 (2009-03-01), Hubbs et al.
patent: 1 378 510 (2004-01-01), None
patent: 1 541 574 (2005-06-01), None
patent: 2825706 (2001-06-01), None
patent: 11335375 (1999-12-01), None
patent: WO 01/30780 (2001-05-01), None
patent: WO 01/38322 (2001-05-01), None
patent: WO 03/013484 (2003-02-01), None
patent: WO 03/024448 (2003-03-01), None
patent: WO 03/075929 (2003-09-01), None
patent: WO 03/076395 (2003-09-01), None
patent: WO 03/076422 (2003-09-01), None
patent: WO 03/087057 (2003-10-01), None
patent: WO 03/092686 (2003-11-01), None
patent: WO 2004/058234 (2004-07-01), None
patent: WO2004/069133 (2004-08-01), None
patent: WO 2004/069823 (2004-08-01), None
patent: WO 2005/030704 (2005-04-01), None
patent: WO 2005/030705 (2005-04-01), None
patent: WO 2005/034880 (2005-04-01), None
patent: WO2005/040101 (2005-05-01), None
patent: WO 2005/092899 (2005-10-01), None
patent: WO 2007/061880 (2007-05-01), None
Romagnoli, et al., J. Med. Chem., vol. 48, pp. 7906-7910 (2005).
Hubbs, J. L., U.S. Appl. No. 11/918,912 Official Action mailed Nov. 27, 2009.
Hubbs, J. L., U.S. Appl. No. 11/918,913 Official Action mailed Oct. 7, 2009.
Notice of Allowance mailed Jul. 6, 2010 in U.S. Appl. No. 11/918,913.
Methot Joey
Miller Thomas A.
Witter David J.
Chung Susannah
Merck Sharp & Dohme Corp.
Muthard David A.
Su Li
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