Benzothiophene derivatives

Details Benzothiophene derivatives Benzothiophene derivatives

2006-04-14

2010-11-16

Chung, Susannah (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S422000, C548S525000, C548S527000, C549S051000, C549S058000

Reexamination Certificate

active

07834034

ABSTRACT:
The present invention relates to a novel class of benzothiophene amide derivatives. The hydroxamic acid compounds can be used to treat cancer. The benzothiophene amide compounds can also inhibit histone deacetylase and are suitable for use in selectively inducing terminal differentiation, and arresting cell growth and/or apoptosis of neoplastic cells, thereby inhibiting proliferation of such cells. Thus, the compounds of the present invention are useful in treating a patient having a tumor characterized by proliferation of neoplastic cells. The compounds of the invention may also be useful in the prevention and treatment of TRX-mediated diseases, such as autoimmune, allergic and inflammatory diseases, and in the prevention and/or treatment of diseases of the central nervous system (CNS), such as neurodegenerative diseases. The present invention further provides pharmaceutical compositions comprising the hydroxamic acid derivatives and safe dosing regimens of these pharmaceutical compositions, which are easy to follow, and which result in a therapeutically effective amount of the hydroxamic acid derivatives in vivo.

REFERENCES:
patent: 5244893 (1993-09-01), Elbe et al.
patent: 5369108 (1994-11-01), Breslow et al.
patent: 5700811 (1997-12-01), Breslow et al.
patent: 5932616 (1999-08-01), Breslow et al.
patent: 6087367 (2000-07-01), Breslow et al.
patent: 6511990 (2003-01-01), Breslow et al.
patent: 6777425 (2004-08-01), Burli et al.
patent: 7141680 (2006-11-01), Botyanszki et al.
patent: 2003/0139404 (2003-07-01), Haag et al.
patent: 2004/0063645 (2004-04-01), Botyanszki et al.
patent: 2004/0106599 (2004-06-01), Delorme et al.
patent: 2004/0142953 (2004-07-01), Delorme et al.
patent: 2004/0157841 (2004-08-01), Fertig et al.
patent: 2004/0192744 (2004-09-01), Haag et al.
patent: 2005/0288282 (2005-12-01), Delorme et al.
patent: 2007/0213392 (2007-09-01), Miller et al.
patent: 2009/0012075 (2009-01-01), Miller et al.
patent: 2009/0062297 (2009-03-01), Heidebrecht et al.
patent: 1 541 574 (2005-06-01), None
patent: 1 378 510 (2006-06-01), None
patent: 2825706 (2001-06-01), None
patent: 11335375 (1999-12-01), None
patent: WO 01/30780 (2001-05-01), None
patent: WO 01/38322 (2001-05-01), None
patent: WO 03/013484 (2003-02-01), None
patent: WO 03/024448 (2003-03-01), None
patent: WO 03/075929 (2003-09-01), None
patent: WO 03/076395 (2003-09-01), None
patent: WO 03/076422 (2003-09-01), None
patent: WO 03/087057 (2003-10-01), None
patent: WO 03/092686 (2003-11-01), None
patent: WO2004/026264 (2004-04-01), None
patent: WO 2004/058234 (2004-07-01), None
patent: WO2004/069133 (2004-08-01), None
patent: WO 2004/069823 (2004-08-01), None
patent: WO 2004/069826 (2004-08-01), None
patent: WO 2005/030704 (2005-04-01), None
patent: WO 2005/030705 (2005-04-01), None
patent: WO 2005/034880 (2005-04-01), None
patent: WO 2005/092899 (2005-10-01), None
patent: WO 2006/115833 (2006-11-01), None
patent: WO 2006/115835 (2006-11-01), None
Romagnoli, et al., J. Med. Chem., vol. 48 (24), pp. 7906-7910 (2005).
Methot, J., U.S. Appl. No. 11/918,911 Official Action mailed Oct. 1, 2009.
Hubbs, J. L., U.S. Appl. No. 11/918,912 Official Action mailed Nov. 27, 2009.

Affiliated with

Also associated with

Rating

Benzothiophene derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Benzothiophene derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Benzothiophene derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4207955