Benzothiophene compounds, intermediates, processes, compositions

Details Benzothiophene compounds, intermediates, processes, compositions Benzothiophene compounds, intermediates, processes, compositions

1997-09-19

1998-12-01

Chang, Ceila

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514146, 5142335, 514442, 514443, 540596, 544146, 546202, 548525, 549 51, A61K 31445, C07D33364, C07D40910

Patent

active

058439633

ABSTRACT:
The invention provides benzothiophene compounds, of formula I, ##STR1## wherein R1, R2, R3, R4 and n are as defined in the specification, formulations, and methods of inhibiting bone loss or bone resorption, particularly osteoporosis, and cardiovascular-related pathological conditions, including hyperlipidemia, and other cardiovascular pathologies.

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Crenshaw, R.R., et al, J. Med. Chem. 14(12):1185-1190 (1971).
Jones, C.D., et al, J. Med. Chem. 27: 1057-1066 1984.
Jones, C.D., et al, J. Med. Chem. 35: 931-938 1992.

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