Benzothiophen analogs as antiviral agents

Details Benzothiophen analogs as antiviral agents Benzothiophen analogs as antiviral agents

1993-08-02

1995-06-13

Fan, Jane T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514337, 546 62, 546274, A61K 31435, C07D49506

Patent

active

054243157

ABSTRACT:
Benzothiophene analogs useful to treat herpes viral infections, particularly cytomegalovirus, are provided. These antiviral agents have the structural formula (I) ##STR1## wherein R and R.sup.1 are as defined herein, and may be in free base or acid addition salt form. Pharmaceutical compositions are provided containing the antiviral agents, as are methods of treating herpes-infected individuals.

REFERENCES:
patent: 3933827 (1976-01-01), Brossi et al.
patent: 4018780 (1977-04-01), Lappi et al.
patent: 4045565 (1977-08-01), Le Pecq et al.
patent: 4310667 (1982-01-01), Le Pecq et al.
patent: 4334070 (1982-06-01), Berger et al.
patent: 4483989 (1984-11-01), Le Pecq et al.
patent: 4851417 (1989-07-01), Archer
patent: 4897398 (1990-01-01), Gros et al.
Shafiee et al. CA 84 (25): 180104C, 1976.
Shafiee et al. Photochemical synthesis of [1]benzothieno[3,2-h]isoquinoline (1976) J. Heterocyclic Chem. 13:141-144.
Duke et al. In vitro and in vivo activities of phosphate derivatives of 9-(1,3-dihydroxy-2-propoxymethyl)guanine against cytomegaloviruses. (1986) Antiviral Res. 6:299-308.
Cheng et al. Unique spectrum of activity of 9-[(1,3-dihydroxy-2-propoxy)methyl]guanine against herpesviruses in Vitro and its mode of action against herpes simplex virus type 1. (1983) Proc. Natl. Acad. Sci. USA 80:2767-2770.

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