Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2006-03-28
2006-03-28
Lambkin, Deborah C. (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
Reexamination Certificate
active
07019023
ABSTRACT:
Substituted benzothiepine 1,1-dioxide derivatives of formula I:in which R1, R2, R3, R4, R5and Z have the meanings indicated, and their physiologically tolerable salts and physiologically functional derivatives and a process for their preparation are described. The compounds are suitable, for example, as hypolipidemics.
REFERENCES:
patent: 3287370 (1966-11-01), Mohrbacher et al.
patent: 3389144 (1968-06-01), Mohrbacher et al.
patent: 3520891 (1970-07-01), Mohrbacher et al.
patent: 3694446 (1972-09-01), Houlihan et al.
patent: 3758528 (1973-09-01), Malen et al.
patent: 3770728 (1973-11-01), Bourquin et al.
patent: 3821249 (1974-06-01), Malen et al.
patent: 3853915 (1974-12-01), Bourquin et al.
patent: 3928383 (1975-12-01), Kaplan et al.
patent: 3954764 (1976-05-01), Gerecke et al.
patent: 4044010 (1977-08-01), Gerecke et al.
patent: 4045570 (1977-08-01), Dörhöfer et al.
patent: 4153612 (1979-05-01), McCall
patent: 4185109 (1980-01-01), Rosen
patent: 4207239 (1980-06-01), McCall
patent: 4237296 (1980-12-01), Gadient
patent: 4247553 (1981-01-01), McCall
patent: 4251526 (1981-02-01), McCall
patent: 4436749 (1984-03-01), Hatinguais et al.
patent: 5037825 (1991-08-01), Klaus et al.
patent: 5158943 (1992-10-01), Sohda et al.
patent: 5164387 (1992-11-01), Klaus et al.
patent: 5169857 (1992-12-01), Angerbauer et al.
patent: 5300522 (1994-04-01), Klaus et al.
patent: 5420273 (1995-05-01), Klaus et al.
patent: 5430116 (1995-07-01), Kramer et al.
patent: 5491152 (1996-02-01), Wilde et al.
patent: 5547975 (1996-08-01), Talley et al.
patent: 5594001 (1997-01-01), Teleha et al.
patent: 5602152 (1997-02-01), Berthelone et al.
patent: 5652252 (1997-07-01), Berthelone et al.
patent: 5670532 (1997-09-01), Talley et al.
patent: 5886016 (1999-03-01), Talley et al.
patent: 5994391 (1999-11-01), Lee et al.
patent: 5998400 (1999-12-01), Brieaddy et al.
patent: 6013809 (2000-01-01), Zimmer et al.
patent: 6083977 (2000-07-01), Boehm et al.
patent: 6107494 (2000-08-01), Lee et al.
patent: 6143755 (2000-11-01), Bocan
patent: 6180660 (2001-01-01), Whitney et al.
patent: 6221897 (2001-04-01), Frick et al.
patent: 6235771 (2001-05-01), Shiraishi et al.
patent: 6262277 (2001-07-01), Lee et al.
patent: 6268392 (2001-07-01), Keller et al.
patent: 6277831 (2001-08-01), Frick et al.
patent: 6369220 (2002-04-01), Li et al.
patent: 6387924 (2002-05-01), Lee et al.
patent: 6387944 (2002-05-01), Frick et al.
patent: 6420417 (2002-07-01), Keller et al.
patent: 6441022 (2002-08-01), Frick et al.
patent: 2002/0032329 (2002-03-01), Babiak et al.
patent: 2002/0061888 (2002-05-01), Keller et al.
patent: 2003/0017996 (2003-01-01), Frick et al.
patent: 2011806 (1970-10-01), None
patent: 0067086 (1982-12-01), None
patent: 0250265 (1987-12-01), None
patent: 0350846 (1990-01-01), None
patent: 0508425 (1992-10-01), None
patent: 0781278 (1997-07-01), None
patent: 0791592 (1997-08-01), None
patent: 0922703 (1999-06-01), None
patent: 2661676 (1991-11-01), None
patent: 2698873 (1994-06-01), None
patent: 1211258 (1970-11-01), None
patent: 1428110 (1976-03-01), None
patent: 506297 (1976-03-01), None
patent: 550982 (1977-03-01), None
patent: 591146 (1978-01-01), None
patent: WO 93/16055 (1993-08-01), None
patent: WO 96/08484 (1996-03-01), None
patent: WO 96/16051 (1996-05-01), None
patent: WO 97/33882 (1997-09-01), None
patent: WO 98/38182 (1998-09-01), None
patent: WO 98/40375 (1998-09-01), None
patent: WO 98/55118 (1998-12-01), None
patent: WO 99/32478 (1999-07-01), None
patent: WO 00/01687 (2000-01-01), None
patent: WO 00/38725 (2000-07-01), None
patent: WO 01/68637 (2001-09-01), None
patent: WO 02/08211 (2002-01-01), None
Ali, M., et al., “Reactions with 2,3,4,5-Tetrahydro-benzo (B) Thiepin-5-One and Its Derivatives,”J. Prakt. Chem.316(2):259-266(1974).
Almena J. et al, “Reductive Opening of Thiophthalan: A New Route to Functionalised Sulfur-Containing Compounds.”, J. Org. Chem., vol. 61, pp. 1859-1862, 1996.
Baumgarth M. et al, “Bicyclic Acylguanidine Na+/H+Antiporte Inhibitors”, J. Med. Chem. vol. 41, pp. 3736-3747, 1998.
Bentley, K. W. et al., “Pharmaceutical Antihypertensive and Vasodilator Compositions”, Chemical Abstracts, vol. 85, p. 516, (1976).
Berthelon et al., “Benzoxepinopyridine derivatives,” Chemical Abstracts, vol. 121, p. 1161 (1994).
Bohme, H. and Haack, B., “[Derivatives of 1,3,4,5-tetrahydro-2-benzothiepin with a basic side chain in the 1-position],”Arch. Pharm. Ber. Dtsch. Pharm. Ges.302(1):72-74 (1969).
Braun et al. “2,3,4,5,6-Penta-O-Acetyl-D-Gluconic Acid and 2,3,4,5,6-Penta-O-Acetyl-D-Gluconyl Chloride,” Organic Synthesis, vol. 5, pp. 887-891 (1973).
Chatterjee, A., et al., “Ring contraction of some 1-benzothiepin derivatives to 1-benzothiophens,”J. Chem. Soc. Perkin Trans.1:1707-1711 (1981).
Corelli F. et al., “Diltiazem-like Calcium Entry Blockers: A Hypothesis of the Receptor-Binding Site Based on a Comparative Molecular Field Analysis Model.”, J. Med. Chem., vol. 40, pp. 125-131, 1997.
Deshayes C. et al. “Synthesis of some 4-Acetyl-3,5-dioxo-2,3,4-tetrahydro[1]benzoxepine or Benzothiepine and 6-Acetyl-5,7-dioxo-6,7,8,9-tetrahydor-5H-benzocycloheptene Derivatives”, J. Heterocyclic Chem., vol. 22, No. 6, pp. 1659-1662, (1985).
Ferrari, R., et al., “How do calcium antagonists differ in clinical practice?,”Cardiovascular drugs and therapy8:565-575 (1994).
Hofmann, H. and Dickert, F., “The dynamic behaviour of the 1-methyl-1-benzothiepinium ring system,” Z.Natuforsch. B Anorg. Chem. Org. Chem.36(8):974-977 (1981).
Hofmann, H. and Djafari, H., “Heterocyclic seven-membered ring compounds, xxxiv. A simple synthesis of 1-benzoxepine and 1-benzothiepine,”Z. Natuforsch. B44(2):220-224 (1989).
Hofmann, H. and Djafari, H., “Heterocyclic seven-membered ring compounds, xxviii.—on 5-acetoxy-and 5-methoxy-1-benzothiepine and analogous 1-benzoxepines,”Liebigs Ann. Chem.3:599-604 (1985).
Hofmann, H. and Djafari, H., “Heterocyclic seven-membered ring compounds, xxxi.—the photochemical behaviour of monosubstituted 1-benzothiepines,”Liebigs Ann. Chem.505-508 (1987).
Hofmann, H. and Heidrich, R., “Heterocyclic seven-membered ring compounds, xxiv. Photochemical reaction of 2-methyl-4-phenyl-1-benzothiepins,”Z. Naturforsch. B. Anorg. Chem. Org. Chem.37(10):1344-1345 (1982).
Hofmann, H. and Heidrich, R., “Heterocyclic Seven-Membered Ring Compounds XXIII. Synthesis and Thermolytic Behavior of 2-Methyl-4-Phenyl-1-benzothiepins”Z. Naturforsch. B34(8):1145-1148 (1979).
Hofmann, H. and Loew, G., “Heterocyclic seven-membered ring compounds, xxvii. Synthesis and thermal reactivity of 1,2-dimethyl-4-phenyl-1-benzothiepinium salts,”Z. Naturforsch. B Anorg. Chem. Org. Chem.39(7):985-989 (1984)
Hofmann, H., et al., “Heterocyclic seven-membered ring compounds, xxv—synthesis and thermolysis of substituted 1-methyl-4-phenyl-1-benzothiepinium salts,”Liebigs Ann. Chem.3:425-432 (1983).
Hofmann, H., et al., “Synthesis of stable 1-benzothiepins,”Angew Chem. Int. Ed. Engl.11(5): 423-424 (1972).
Huckle et al., “4-Amino-2,3,4,5-tetrahydro-1-benzoxepin-5-ols , 4-Amino-2,3,4,5-tetrahydro-1-benzothiepin-5-ols and related compounds,”J. Chem. Soc. C12:2252-2260 (1971).
Ishino Y. et al., “Novel Synthesis of 4,5-Bis(arylthio)-2,3,4,5-tetrahydro-1-benzothiepins: Noteworthy Cyclization by the Reaction of 2-Butynedion with Arenethiols in the Presence of Zinc Iodide.”, Communications, pp. 827-829, 1987.
Jilek J. et al., “8-Chloro and 8-Methylthio Derivatives of 10-Piperazino-10,11-DiHydrodisenzo[b,f]Thiepins; New Compounds and New Procedures”, Neurotropic and Psychotropic Agents: Part CLXXVII, Journal 48, pp. 906-927, (1983).
Journal Bioorganicheskaya khimiya, (Bioorganic chemistry), Publisher Nauka, Academy of Sciences of the USSR, v. 9, No 10, 1983, pp. 1357-1358 and partial translation.
Journal of organic chemi
Enhsen Alfons
Frick Wendelin
Glombik Heiner
Heuer Hubert
Aventis Pharma Deutschland GmbH
Finnegan, Henderson Farabow, Garrett and Dunner L.L.P.
Lambkin Deborah C.
LandOfFree
Benzothiepine 1, 1-dioxide derivatives, a process for their... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Benzothiepine 1, 1-dioxide derivatives, a process for their..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Benzothiepine 1, 1-dioxide derivatives, a process for their... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3586502