Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1997-11-12
1999-09-14
Tsang, Cecilia J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514 19, 5142242, 546146, 544105, 544283, 534136, 534788, A61K 3154
Patent
active
059523280
ABSTRACT:
The present invention is directed to novel benzothiazo and related heterocyclic group-containing inhibitors of cysteine or serine proteases. Methods for using the same are also described.
REFERENCES:
patent: 3591584 (1971-07-01), Lombardino et al.
patent: 3960854 (1976-06-01), Novello
patent: 4585793 (1986-04-01), Powers
patent: 4889851 (1989-12-01), Oku et al.
patent: 5004742 (1991-04-01), Satoh et al.
patent: 5384411 (1995-01-01), Robotti et al.
patent: 5416094 (1995-05-01), Lal et al.
patent: 5563127 (1996-10-01), Amparo et al.
Zenno, Chem. Abstr. 72, 111525f, 1970.
Close, W.J. et al., "Synthesis of Potential Diuretic Agents. III. Derivatives of 6-Chloro-3,4-dihydro-2-methyl-7-sulfamyl-2H-1,2,4-bendothiadiazine 1,1-Dioxide", J. Org. Chem., 1961, 26, 3423-3427.
Short, J.H. et al. Synthesis of Potential Diuretic Agents. IV. Bromo Derivatives of 1,2,4-Benzothiadizine 1,1-Dioxide, J. Org. Chem. 1961, 26, 3428-3431.
Swett, L. et al., Synthesis of Potential Diuretic Agents. V. Dreivaties of New Tricyclic System, J. Org. Chem., 1961, 26, 3431-3433.
Biressi, M.G. et al., "Derivati della Diidrobenzotiadianzina e del Tetraidro-4-Chinazolinone e loro Prodotti di Idrogenolisi", Farmeco. Ed. Sci. (Italy)., 1969, 24, 199-220.
Catsoulacos, P. et al., "Synthesis of Some N-Substituted 4,5-Dihydro-7,8-dimethoxybenzothiazepin-3-one 1,1-Dioxides", J. Heterocyclic Chem., 1976, 13, 1309-1314.
Essien, H. et al., "Synthesis of Diethylenetriaminepentaacetic Acid Conjugated Inulin and Utility for Cellular Uptake of Liposomes", J. Med. Chem., 1988, 31, 898-901.
Girard, Y. et al., "A New Synthesis of 1,2,4-Benzothiadiazines and a Selective Preparation of o-Aminobenzenesulphonamides", J. Chem. Soc. Perkin I, 1979, 1043-1047.
Harbeson, S.L. et al., "Stereospecific Synthesis of Peptidyl .alpha.-Keto Amides as Inhibitors of Calpain", J. Med. Chem., 1994, 37, 2918-2929.
Hashizume, H. et al., "Synthesis and Biological Activity of New 3-Hydroxy-3-methylglutaryl Coenzyme-A (HMG-CoA) Synthase Inhibitors: 2-Oxetanones with a Side Chain Mimicking the Folded Structure of 1233A", Chem. Pharm. Bull., 1994, 42, 512-520.
Hein,G.E. et al., "Steric Course and Specificity of .alpha.-Chymotrypsin-catalyzed Reactions. I.", J. Am. Chem.Soc., 1962, 84, 4487-4494.
Lee, W.J. et al., "Factors Influencing the Binding of Calpain I", Biochem. Internat., 1990, 22, 163-171.
Lehninger, Biochemistry, 1975, 2nd Ed., Worth Publishers, Inc., 73-75.
Lombardino, J.G. et al., "Synthesis and Antiinflammatory Activity of Some 3-Caboxamides of 2-Alkyl-4-hydroxy-2H-1,2-benzothiazine 1,1-Dioxide", J. Med. Chem., 1971, 14, 1171-1177.
Lombardino, J.G. et al., "Potent Antiinflammatory N-Heterocyclic 3-Caboxamides of 4-Hydroxy-2-methyl-2H-1,2-benzothiazine 1,1-Dioxide", J. Med. Chem., 1973, 16, 493-496.
Maeda, H. et al., "Synthesis and Central Nervous System Actions of Thyrotropin-Releasing Hormone Analogs Containing a 1-Oxo-1,2,3,4-tetrahydroisoquinoline Moiety", Chem.Pharm. Bull., 1988, 36, 190-201.
Ocain, T.D. et al., ".alpha.-Keto Amide Inhibitors of Aminopeptidases", J. Med. Chem., 1992, 35, 451-456.
Popel, W. et al., "Derivate von 6,7-Dimethoxy-1 thiaisochroman-1,1-dioxid und 3,4-Dihydro-6,7-Dimethoxy-2H-1,2-benzothiazin-1,1-dioxid", Pharmazie, 1980, 35, 266-278.
Wrobel, J. et al., "Synthesis of Spiro(Oxazolidinediones): Spiro Heterocycles, 1994, 38, 1823-1838.
Bihovsky Ron
Tao Ming
Wells Gregory J.
Cephalon Inc.
Lukton David
Tsang Cecilia J.
LandOfFree
Benzothiazo and related heterocyclic group-containing cysteine a does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Benzothiazo and related heterocyclic group-containing cysteine a, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Benzothiazo and related heterocyclic group-containing cysteine a will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1509928