Benzothiazepine esters, their preparation and formulations for t

Details Benzothiazepine esters, their preparation and formulations for t Benzothiazepine esters, their preparation and formulations for t

1991-06-12

1992-06-09

Bond, Robert T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

540491, A61K 3155, C07D28102

Patent

active

051207303

ABSTRACT:
A class of benzothiazepine esters having structures related to that of diltiazem are provided which possess vasodilating activity while being virtually free of cardiodepressive effects. The esters are useful in the treatment of arterial hypertension and disturbances of the cerebral circulation.
The compounds have the general formula I ##STR1## wherein R represents hydrogen or an electronegative group (preferably a halogen atom, or a nitro, trifluoromethyl or methoxy group); and

REFERENCES:
patent: 3562257 (1971-02-01), Kugita et al.
Merck Index, 11th edition, 1989, Merce & Co., Rahway, N.J., p. 505, item 3188.
Joslyn et al., J. Med. Chem., vol. 31, pp. 1489-1492 (1988).

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