Benzoquinolizines having blood pressure lowering activity, and i

Details Benzoquinolizines having blood pressure lowering activity, and i Benzoquinolizines having blood pressure lowering activity, and i

1979-05-10

1980-11-25

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

546 95, A61K 3147, C07D45506

Patent

active

042359104

ABSTRACT:
The invention concerns benzoquinolizines of the general formula (I) ##STR1## and the pharmaceutically acceptable acid addition salts thereof, wherein R.sup.1 and R.sup.2 which may be the same or different, each represent hydrogen, lower alkyl, lower alkoxy or halogen and R represents --CXNHR.sup.3 (where X is O, S or .dbd.NH and R.sup.3 is hydrogen or lower alkyl) or --(CH.sub.2).sub.n R.sup.4 (where n is 0 or 1 and R.sup.4 is aryl). These compounds lower blood pressure. Some are also anti-ulcer agents. The compounds in which R.sup.1, R.sup.2 and R are as defined above, with the proviso that when R is phenyl, R.sup.1 and R.sup.2 are not both lower alkoxy, are novel.

REFERENCES:
patent: 3634431 (1972-01-01), Van Dyke, Jr.
patent: 3635986 (1972-01-01), Van Dyke, Jr.
patent: 4076820 (1978-02-01), Archibald, et al.
Van Dyke, et al., J. Med. Chem. vol. 15, pp. 91-94 (1972).
Kawanishi, Chemical & Pharmaceutical Bulletin (Japan) vol. 10, No. 3, pp. 185-190 (1962).
Gerszberg, et al., Anales Asoc. Quim. Argentina, vol. 60, pp. 331-346 (1972).

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