Benzoquinolizines as .alpha..sub.2 -adrenoceptor antagonists

Details Benzoquinolizines as .alpha..sub.2 -adrenoceptor antagonists Benzoquinolizines as .alpha..sub.2 -adrenoceptor antagonists

1984-01-03

1985-10-29

Schwartz, Richard A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546 95, 546 96, A61K 3147, C07D45506

Patent

active

045501149

ABSTRACT:
The invention concerns benzoquinolizines of general formula ##STR1## and their pharmaceutically acceptable acid addition salts. In the formula R.sup.1 and R.sup.2 which may be the same or different each represent hydrogen, lower alkyl, lower alkoxy or halogen, R.sup.3 represents hydrogen or lower alkyl and R.sup.4 represents a heterocyclic radical attached to the SO.sub.2 group through a carbon atom of the heterocyclic ring. The compounds possess .alpha..sub.2 -adrenoceptor antagonistic activity in warm blooded animals.

REFERENCES:
patent: 4076820 (1978-02-01), Archibald et al.
patent: 4183937 (1980-01-01), Ward

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