Benzoquinolizines and use as .alpha..sub.2 -adrenoceptor antagon

Details Benzoquinolizines and use as .alpha..sub.2 -adrenoceptor antagon Benzoquinolizines and use as .alpha..sub.2 -adrenoceptor antagon

1984-03-19

1985-07-02

Jiles, Henry R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

A01N 4340, A61K 31435, C07D45506, C07D22106

Patent

active

045269670

ABSTRACT:
The invention concerns benzoquinolizines of general formula ##STR1## and their pharmaceutically acceptable acid addition salts. In formula (I), R represents hydrogen or lower alkyl, R.sup.1 and R.sup.2 which may be the same or different each represent hydrogen, lower alkyl, lower alkoxy or halogen, R.sup.3 and R.sup.4 which may be the same or different each represents lower alkyl, halo(lower)alkyl or aryl and A represents a lower alkylene group having 1 to 3 carbon atoms in the chain between the two N atoms. The compounds possess .alpha..sub.2 -adrenoceptor antagonistic activity in warm blooded animals.

REFERENCES:
patent: 4076820 (1978-02-01), Archibald et al.
patent: 4154139 (1984-06-01), Ward et al.
Archibald, et al., J. Med. Chem. 1983, (26)(3), 416-420.

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