Benzopyranopyridines as antiglaucoma agents

Details Benzopyranopyridines as antiglaucoma agents Benzopyranopyridines as antiglaucoma agents

1976-08-04

1979-01-23

Meyers, Albert T.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

424244, 424256, 424263, 424273, 424273R, A01N 900, A01N 922, A01N 928

Patent

active

041361830

ABSTRACT:
A method of reducing intra-ocular pressure in mammalian patients comprising administering to a glaucoma patient a therapeutically effective amount of a compound of the formula ##STR1## WHEREIN, IN THE C ring, X is CH.sub.2, S, ##STR2## or NR.sub.4 where R.sub.4 is H, loweralkyl, loweralkenyl, loweralkynyl or loweralkanoyl; n is an integer of 0 to 3; m is an integer of 0 to 3, or the C ring is a quinuclidine ring ##STR3## each R.sub.1 is loweralkyl, and when taken together, the substituents R.sub.1 R.sub.1 form oxygen; R.sub.2 is a C.sub.1 -C.sub.20 straight or branched chain alkyl, cycloalkyl, or wherein Y is a straight or branched chain alkylene group having from 1 to 10 carbon atoms, and each R.sub.5, R.sub.6 and R.sub.7 are the same or different members of the group consisting of H, halo or loweralkyl; R.sub.3 is H or ##STR4## WHEREIN Y' is a straight or branched chain alkylene group having 1 to 8 carbon atoms, a is an integer from 1 to 4, b is an integer from 1 to 4, Z is CH.sub.2, O, S or NR.sub.9 where R.sub.9 is H or loweralkyl, with the provision that when Z is O, S or NR.sub.9, the sum of a and b is 3 or 4, and R.sub.8 is H or loweralkyl; and the pharmaceutically acceptable salts thereof.

REFERENCES:
patent: 3777028 (1973-12-01), Harris et al.
patent: 3787424 (1974-01-01), Pars et al.
patent: 3795736 (1974-03-01), Harris et al.
patent: 3798326 (1974-03-01), Harris et al.
patent: 3838158 (1974-09-01), Pars et al.
patent: 3878219 (1975-04-01), Lee
patent: 3896137 (1975-07-01), Baile et al.
patent: 3901926 (1975-08-01), Winn et al.
patent: 3905969 (1975-09-01), Harris et al.
patent: 3932432 (1976-01-01), Winn
patent: 3961057 (1976-06-01), Brown et al.
patent: 3962266 (1976-06-01), Brown et al.
patent: 3962448 (1976-06-01), Baile et al.
patent: 3984546 (1976-10-01), Brown et al.
Chem. Abst. 82 25826(e) (1975) Gence -- "Action of Vasoactive Pharmaceuticals on Glaucoma".

Affiliated with

Also associated with

Rating

Benzopyranopyridines as antiglaucoma agents does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Benzopyranopyridines as antiglaucoma agents, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Benzopyranopyridines as antiglaucoma agents will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2273408