Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1975-01-03
1976-06-01
Drezin, Norman A.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
424246, 424250, 424263, A61K 31535
Patent
active
039610578
ABSTRACT:
Substituted benzopyrano[3,4-c]pyridines having the following structural formula are disclosed: ##SPC1##
In the above formula, R.sub.1 and R.sub.2 are hydrogen, a hydroxyl group or a lower alkoxyl group of from 1 to 6 carbon atoms; R.sub.3 is hydrogen or a lower alkyl group of from 1 to 6 carbon atoms and X is an oxygen atom, a sulfur atom, a methylene group or a nitrogen atom substituted by hydrogen, a lower alkyl group of from 1 to 6 carbon atoms or a lower alkanoyl group of from 1 to 6 carbon atoms. The compounds of this invention are prepared by reacting an R.sub.1, R.sub.2 -substituted phenol with a 3-carbethoxy-4-piperidone in the presence of an acid catalyst to give an intermediate R.sub.1, R.sub.2 -substituted benzopyrano[3,4-c]pyridine. N-aminoalkylbenzopyrano[3,4-c]pyridines are obtained by treating the benzopyrano[3,4-c]pyridine with an appropriately substituted alkyl halide. The compounds of this invention are useful as bronchodilators for the treatment of bronchial asthma.
REFERENCES:
patent: 3396165 (1968-08-01), Bolger
patent: 3429889 (1969-02-01), Shulgin et al.
patent: 3514464 (1970-05-01), Pars et al.
patent: 3689497 (1972-09-01), Brown et al.
Brown Richard E.
Shavel, Jr. John
Chow Frank S.
Drezin Norman A.
Graddis Albert H.
Warner-Lambert & Company
Yahwak George M.
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