Benzopyrancarboxamide derivatives, salts thereof, process for th

Details Benzopyrancarboxamide derivatives, salts thereof, process for th Benzopyrancarboxamide derivatives, salts thereof, process for th

1995-06-13

1996-03-26

Springer, David B.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D47106, A61K 3140

Patent

active

055022090

ABSTRACT:
There are disclosed a benzopyrancarboxamide derivative of the formula ##STR1## wherein R.sup.1 is hydrogen atom or a lower alkyl group; R.sup.2 is hydrogen atom, a lower alkyl group, halogen atom, an amino radical or an acylamino group; R.sup.3 is hydrogen atom, a lower alkyl group, a lower alkoxy group or halogen atom; dotted line is a possible double bond; and n is an integer of 1-5,
and a pharmacologically acceptable salt of the compound, a process for the preparation of the compound and salt as well as use thereof.

REFERENCES:
The Merck Index, 10th Ed. 6063.
"Novel Benzamides as Selective and Potent Gastrokinetic Agents. 2..sup.1 Synthesis and Structure-Activity Relationships of 4-Amino-5-chloro-ethoxy-N- 4-(4-flurobenzyl)-2-morpholinyl!methyl!benzami de Citrate AS-4370) and Related Compounds," Kato et al., J. Med. Chem. 1991, 34, pp. 616-624.
"5-Hydroxytryptamine, receptors mediate relaxation of the rat oesophageal tunica muscularis mucosae," G. S. Baxter et al., Naunyn-Schmiedeberg's Archives of Pharmacology, 1991, vol. 343 pp. 439-446.

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