Benzopyran intermediates for use in manufacturing thromboxane A.

Details Benzopyran intermediates for use in manufacturing thromboxane A. Benzopyran intermediates for use in manufacturing thromboxane A.

1988-12-13

1991-02-12

Lee, Mary C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549281, 546269, 548159, 548217, 548221, 562427, 562470, 564 82, 564 88, 564308, 568326, 568328, 568376, C07D31178, C07D41302, C07C 5948, C07C21101

Patent

active

049925636

ABSTRACT:
This invention relates to several intermediates useful in preparing thromboxane A.sub.2 inhibiting (.+-.)7-[3.alpha.-[1-[[(phenylamino)-thioxomethyl]hydrazono]ethyl]-1.alpha ., 4.alpha.-bicyclo[2.2.1]hept-2.beta.-yl]-heptenoic acids and useful derivatives thereof from (.+-.)octahydro-1.alpha.-methyl-3a.alpha., 7a.alpha.-4.alpha.,7.alpha.-methano-2H-inden-2-ones.

REFERENCES:
patent: 4416896 (1983-11-01), Nakane et al.
patent: 4456617 (1984-06-01), Nakane et al.
Wilson, et al "Prostaglandin Endoperoxide . . . " Advances in Pros., Throm. & Leukotriene Research vol. 14, 1985, pp. 393-425.
Nakane et al "Aza-Substituted . . . " Advances in Pros., Throm. & Leukotriene Research, 1985, vol. 15, 291.
Sprague et al "Stereocontrolled Synthesis of . . . " Advances in Pros., Throm. & Leukotriene Research, 1980, vol. 6, pp. 493-496.
Christl et al. Chem. Abstracts; vol. 103, No. 23; 195960p (1985).
Furuichi et al. Chem. Abstracts, vol. 82, No. 17; 111970d (1975).
Greico et al., Chem. Abstracts, vol. 80, No. 17, 95178c (1974).
Armstrong, R. A. "Competitive Antagonism at Thromboxane Receptors in Human Platelets" Br. J. Pharmac. (1985) 84, pp. 595-607.

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