Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2007-10-09
2007-10-09
Shameem, Golam M. M. (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C548S300100, C548S311100, C548S311400, C514S385000, C514S396000
Reexamination Certificate
active
10523015
ABSTRACT:
The present invention relates to benzopyran derivatives substituted with secondary amines including imidazole, their preparation, and pharmaceutical compositions containing them. The present invention is pharmacologically useful for the treatment of cancer, rheumatoid arthritis, and diabetic retinopathies through anti-angiogenic properties, and also pharmacologically useful in the protection of heart and neuronal cells against ischemia-reperfusion injury or preserving organs.
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Grover, G.J., et al., “Pharmacologic Characterization of BMS-191095, a Mitochondrial KATPOpener with No Peripheral Vasodilator or Cardiac Action Potential Shortening Activity”,The Journal of Pharmacology and Experimental Therapeutics, vol. 297, No. 3, pp. 1184-1192, (2001).
Ding, C.Z., et al., “Cardio selective Antiischemic ATP-Sensitive Potassium Channel (KATP) Openers. 6. Effect of Modifications at C6 of Benzopyranyl Cyanoguanidines”,Journal of Medicinal Chemistry, vol. 42, No. 18, pp. 3711-3717, (1999).
Rovnyak, G.C., et al., “Cardio selective Antiischemic ATP-Sensitive Potassium Channel (KATP) Openers. 5. Identification of 4-(N-Aryl)-Substituted Benzopyran Derivatives with High Selectivity”,Journal of Medicinal Chemistry, vol. 40, No. 1, pp. 24-34, (1997).
Choi Sang-Un
Hwang Sun Kyung
Kim Nak Jeong
Lee Byung-Ho
Lee Chong Ock
Goldberg Joshua B.
Harkins Tanya E.
Korea Research Institute of Chemical Technology
Nath Gary M.
Shameem Golam M. M.
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