Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2004-05-28
2008-09-02
Anderson, Rebecca L (Department: 1626)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
active
07420060
ABSTRACT:
The present invention relates to benzopyran derivatives substituted with a thioxobenzoxazole derivative, or pharmaceutically acceptable salts thereof, processes for preparing the same and a pharmaceutical composition containing the above as an effective ingredient Benzopyran derivatives substituted with thioxobenzoxazole derivatives, represented in <Formula 1>, have the function of protecting heart from ischemia-reperfusion both in vivo and in vitro, so that a pharmaceutical composition containing benzopyran derivatives substituted with thioxobenzoxoazole derivatives or pharmaceutically acceptable salts thereof of the present invention as an effective ingredient can be effectively used for the protection of tissues influenced by ischemia-reperfusion, for example, for the protection of heart, nervous cells, brain, retinal cells, storage organs, etc, and for the treatment of diseases caused by ischemia-reperfusion.
REFERENCES:
Parker, J. Angina Pectoris: A Review of Current and Emerging Therapies. The American Journal of Managed Care, 2004, 10, S332-S338.
Vilas-Boas, et al. Current Insights into the Modern Treatment of Decompensated Heart Failure. 2006, 87, 329-337.
Thrombolytic therapy [online].[retrieved on Nov. 19, 2007]. Retrieved from the Internet, URL; http://www.nlm.nih.gov/medlineplus/ency/article/007089.htm>.
RN 94544-88-4, CAPLUS retrieved on Jun, 10, 2008.
Gary J. Grover, Pharmacology of ATP-Sensitive Potassium Channel . . . , Can. J. Physiol. Pharmacol., vol. 75, pp. 309-315 (1997).
Gary D. Lopaschuk, et al, Manipulation of Energy Metabolism in the Heart, Science & Medicine, pp. 42-51, ((1997).
A.A. Starkov, “Mild” Uncoupling of Mitochondria, Bioscience Reports. vol. 17, No. 3, pp. 273-279, (1997).
Skulachev, Vladimir P., et al., Role of Uncoupled and Non-Coupled Oxidations in Maintenance . . . , Quarterly Reviews of Biophysics, vol. 29, pp. 169-202, (1996).
Okubo, Shinji, et al., Myocardial Preconditioning: Basic . . . , Molecular and Cellular Biochemistry, vol. 196, pp. 3-12, (1999).
Moreau, Jean-Luc, et al., Central Adenosine A . . . , Brain Research Reviews, vol. 31, pp. 65-82, (1999).
Hwang Sun Kyung
Kim Nak Jeong
Kim Sun Ok
Kim Tae Mi
Lee Byung Ho
Anderson Rebecca L
Lucas & Mercanti LLP
Schaeffler KG
Young Shawquia
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