Benzopyran derivatives substituted with a benzimidazole...

Details Benzopyran derivatives substituted with a benzimidazole... Benzopyran derivatives substituted with a benzimidazole...

2007-12-18

2007-12-18

Saeed, Kamal A. (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

active

10558020

ABSTRACT:
The present invention relates to benzopyran derivatives substituted with a benzimidazole derivative, or pharmaceutically acceptable salts thereof, a preparation method of the same and pharmarceutical compositions containing them. Benzopyran derivatives substituted with a benzimidazole derivative, represented in Formula (1), have the function of protecting heart from ischemia-reperfusion without side effect like vasodilation, so that a pharmaceutical composition containing benzopyran derivatives substituted with a benzimidazole derivative or pharmaceutically acceptable salts thereof of the present invention as an effective ingredient can be effectively used for the protection of tissues influenced by ischemia-reperfusion, for example, for the protection of heart, nervous cells, brain, retinal cells, storage organs, etc. and for the treatment of diseases caused by ischemia-reperfusion.

REFERENCES:
patent: 5466817 (1995-11-01), Atwal
Parker, J. Angina Pectoris: A Review of Current and Emerging Therapies. The American Journal of Managed Care, 2004, 10, S332-S338.
Vilas-Boas, et al. Current Insights into the Modern Treatment of Decompensated Heart Failure. 2006, 87, 329-337.
Gary J. Grover, Pharmacology of ATP-Sensitive Potassium Channel . . . , Can. J. Physiol. Pharmacol., vol. 75, pp. 309-315 (1997).
Gary D. Lopaschuk, et al, Manipulation of Energy Metabolism in the Heart, Science & Medicine, pp. 42-51, ((1997).
A.A. Starkov, “Mild” Uncoupling of Mitochondria, Bioscience Reports. vol. 17, No. 3, pp. 273-279, (1997).
Skulachev, Vladimir P., et al., Role of Uncoupled and Non-Coupled Oxidations in Maintenance . . . , Quarterly Reviews of Biophysics, vol. 29, pp. 169-202, (1996).
Okubo, Shinji, et al., Myocardial Preconditioning: Basic . . . , Molecular and Cellular Biochemistry, vol. 196, pp. 3-12, (1999).
Moreau, Jean-Luc, et al., Central Adenosine A . . . , Brain Research Reviews, vol. 31, pp. 65-82, (1999).

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