Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2006-08-30
2010-11-23
Andres, Janet L (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C549S399000, C549S400000, C549S401000, C549S403000, C549S404000
Reexamination Certificate
active
07838553
ABSTRACT:
The present invention is directed to novel benzopyran derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders related to potassium channel.
REFERENCES:
patent: 4210591 (1980-07-01), Burri
patent: 4631282 (1986-12-01), Cassidy
patent: 4812459 (1989-03-01), Evans et al.
patent: 4931454 (1990-06-01), Baumgarth et al.
patent: 4971982 (1990-11-01), Attwood et al.
patent: 4983612 (1991-01-01), Quagliato et al.
patent: 4987138 (1991-01-01), Cassidy et al.
patent: 5028711 (1991-07-01), Stenzel et al.
patent: 5096914 (1992-03-01), Stenzel et al.
patent: 5112839 (1992-05-01), Gericke et al.
patent: 5118694 (1992-06-01), Attwood et al.
patent: 5171857 (1992-12-01), Quagliato
patent: 5206252 (1993-04-01), Butera et al.
patent: 5225566 (1993-07-01), Butera et al.
patent: 5236935 (1993-08-01), Yoo et al.
patent: 5254555 (1993-10-01), Stemp et al.
patent: 5254557 (1993-10-01), Buckle et al.
patent: 5254578 (1993-10-01), Hashimoto et al.
patent: 5284838 (1994-02-01), Garcia et al.
patent: 5310932 (1994-05-01), Atwal et al.
patent: 5387587 (1995-02-01), Hausler et al.
patent: 5470872 (1995-11-01), Buckle et al.
patent: 6153627 (2000-11-01), Hausler et al.
patent: 2007/0072832 (2007-03-01), Zhang et al.
patent: 0172352 (1986-02-01), None
patent: 0205292 (1986-12-01), None
patent: 0273262 (1988-07-01), None
patent: 0298452 (1989-01-01), None
patent: 0308792 (1989-03-01), None
patent: 0350805 (1990-01-01), None
patent: 0406656 (1991-01-01), None
patent: 0413438 (1991-02-01), None
patent: 2242628 (1991-10-01), None
patent: WO 93/23393 (1993-11-01), None
patent: WO 2005/033073 (2005-04-01), None
Aguilar-Bryan et al.: “Toward Understanding the Assembly and Structure of KATPChannels”; Physiological Reviews vol. 78(1) Jan. 1998; 227-245.
Ashwood, V.A. et al.: “Synthesis and Antihypertensive Activity of Pyran Oxygen and Amide Nitrogen Replacement Analogues of the Potassium Channel Activator Cromakalim”, Journal of Medicinal Chemistry, American Chemical Society, Washington, U.S., vol. 34, No. 11, Nov. 1991, pp. 3261-3267, XP002034759.
Ashwood, V.A. et al.: Synthesis and Antihypertensive Activity of 4-(Cyclic Amido)-2H-1-Benzopyrans:, Journal of Medicinal Chemistry, American Chemical Society. Washington, US, vol. 29, 1986, pp. 2194-2201, XP008050667.
Atwal, K.S. et al.: “Cardioselective Anti-Ischemic ATP-Sensitive Potassium Channel Openers. 3. Structure-Activity Studies of Benzopyranyl Cyanoguanidines”, Journal of Medicinal Chemistry, American Chemical Society, Washington, US, vol. 38, No. 17, 1995, pp. 3236-3245, XP009030005.
Attwood, M.R. et al.: Tetrahedron Letters, Elsevier, Amsterdam, NL, vol. 32, No. 6, 1991, pp. 811-814, XP002082330.
Bergmann, R. et al.: Synthesis and antihypertensive activity of 4-(1,2-dihydro-2-oxo-1-pyridyl)-2H-1-benzoyrans and related compounds, new potassium channel activators:, Journal of Medicinal Chemistry, Feb. 1990, vol. 33, No. 2, pp. 492-504, XP002418874.
Bergmann, R. et al.: “4-Heterocyclyloxy02H-1-Benzopyran Potassium Channel Activators”, Journal of Medicinal Chemistry, American Chemical Society, Washington, US, vol. 33, No. 10, Oct. 1, 1990, pp. 2759-2767, XP000566902.
Buckle, D.R. et al.: “Relaxant Activity of 4-amido-3, 4-dihyro-2H-1-benzopyran-3-ols and 4-amido-2H-1-benzopyrans on guinea pig. isolated trachealis”, Journal of Medicinal Chemistry, Nov. 1990, vol. 33(11) pp. 3028-3034, XP002418873.
Burrell, G. et al.: “Variation in the aromatic ring of cromakalim: antihypertensive activity of pyranopyridines and 6-alkyl-2H-1-benzopyrans”, Journal of Medicinal Chemistry, Nov. 1990, vol. 33, No. 11, pp. 3023-3027, XP002418872.
Edwards, G. et al.: “Structure-Activity Relationships of K+ Channel Openers”.Trends in Pharmacological Sciences, Elsevier, Hayworth, GB, vol. 11, No. 10, Oct. 1990, pp. 417-422, XP002034758.
Gabbutt, et al.: “Reactions of Some 2H-Chromenes and 2H-Thiochromenes with Triazolinediones”, Tetrahedron, Elsevier Science Publishers, Amsterdam, NL, vol. 51, No. 48, Nov. 1995, pp. 13277-13290, XP005249958.
Kabbe, H.J. et al.: “Synthesen und Umsetzungen von-4-Chromanonen”, Angewandte Chemie, VCH Verlagsgesellschaft, Weinheim, DE, vol. 94, 1982, pp. 254-262, XP002418875.
Mannhold, R. et al.: “6-Substituted benzopyrans as potassium channel activators: synthesis, vasodilator properties, and multivariate analysis”, Journal of Medicinal Chemistry, Mar. 25, 1999, vol. 42, No. 6, pp. 981-991, XP002418870.
Robertson, D.W. et al: “Potassium Channel Modulators: Scientific Applications and Therapeutic Promise”, Journal of Medicinal Chemistry, American Chemical Society, Washington, U.S., vol. 33, No. 6, Jun. 1990, pp. 1529-1541, XP002034757.
Salamon, E. et al.: “6-Sulfonylchromenes as highly potent K(ATP)-channel openers”, Journal of Medicinal Chemistry, Feb. 28, 2002, vol. 45, No. 5, pp. 1086-1097, XP002418871.
Vuligonda, V. et al.: “A new class of potent RAR antagonists: dihydroanthracenyl, benzochromenyl and benzothiochromenyl retinoids” Bioorganic & Medicinal Chemistry Letters, Oxford, GB, vol. 9, No. 5, Mar. 8, 1999, pp. 743-748, XP004157605.
Wein, A.J., MD: “Overactive Bladder: Defining the Disease”; the American J. of Managed Care, vol. 6(11) Jul. 2000, S559-S564.
PCT International Search Report for International Appln No. PCT/US06/34128 dated Apr. 12, 2006.
Li Xiaojie
Sui Zhihua
Zhang Xuqing
Andres Janet L
Gallis David E
Janssen Pharmaceutica NV
McKown Jeremy K.
LandOfFree
Benzopyran derivatives as potassium channel openers does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Benzopyran derivatives as potassium channel openers, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Benzopyran derivatives as potassium channel openers will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4233578