Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1990-09-11
1992-06-02
Shen, Cecilia
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514254, 514256, 514312, 514314, 514456, 544298, 544333, 544405, 546153, 546167, 546196, 549467, 549469, A61K 3144, A61K 3147, A61K 3135, C07D40504
Patent
active
051186942
ABSTRACT:
Compounds of the formula ##STR1## wherein R.sup.1 is hydrogen, halogen, trifluoromethyl, nitro, cyano, lower alkyl, lower alkoxycarbonyl, lower alkylthio, lower alkylsulphonyl, lower alkanoyl, aroyl, carbamoyl, mono(lower alkyl)carbamoyl or di(lower alkyl)carbamoyl, R.sup.2 is hydrogen, lower alkyl or phenyl, R.sup.3 is hydrogen or lower alkyl, R.sup.4 and R.sup.5 each is hydrogen or R.sup.4 is hydroxy and R.sup.5 is hydrogen or R.sup.4 and R.sup.5 together are a carbon-carbon bond and R.sup.6 is an aryl or N-heteroaryl group carrying a hydroxy group in the 2-position or, in the case of a N-heteroaryl group, also a N-oxide group in the 2-position,
and pharmaceutically acceptable acid addition salts of these compounds of formula I which are basic, possess pronounced potassium channel activating activity and can be used as medicaments, particularly in the control or prevention of hypertension, congestive heart failure, angina pectoris, peripheral and cerebral vascular disease and smooth muscle disorders.
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Nakatsubo et al., CA 108-5825f (1988).
EP 76075, Derwent No. 83-35014K/15 (1983).
EP 250077, Derwent No. 88-022640/04 (1987).
CA 35760y, vol. 75, 1971.
CA 101:90725w 1984.
Attwood Michael R.
Jones Philip S.
Redshaw Sally
Coletti Ellen C.
Gould George M.
Hoffmann-La Roche Inc.
Isgro William G.
Shen Cecilia
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