Benzopyran and benzoxepin PI3K inhibitor compounds and...

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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Reexamination Certificate



Benzopyran and benzoxepin compounds of Formulas I and II, and including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting lipid kinases including p110 alpha and other isoforms of PI3K, and for treating disorders such as cancer mediated by lipid kinases. Methods of using compounds of Formulas I and II for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.

patent: 4797414 (1989-01-01), Rimbault
patent: 5314889 (1994-05-01), Boigegrain et al.
patent: 5612356 (1997-03-01), Yoshimura et al.
patent: 5985799 (1999-11-01), Tseng
patent: 6187801 (2001-02-01), Jaehne et al.
patent: 6251922 (2001-06-01), Jaehne et al.
patent: 6329407 (2001-12-01), Jaehne et al.
patent: 6476059 (2002-11-01), Jaehne et al.
patent: 7273880 (2007-09-01), Marzabadi et al.
patent: 2004/0082602 (2004-04-01), Hagen et al.
patent: 2005/0277630 (2005-12-01), Chupak et al.
patent: 2006/0100254 (2006-05-01), Betzemeier et al.
patent: 2006/0106013 (2006-05-01), Breitfelder et al.
patent: 2008/0132513 (2008-06-01), Che et al.
patent: WO 01/64675 (2001-09-01), None
patent: WO 2008/019139 (2008-02-01), None
patent: PCT/US2009/038795 (2009-07-01), None
Banaszak et al., “New and efficient RCM in pyridinic series: synthesis of 2H-dihydropyrano- or 2, 3H-dihydrooxepino [3,2-b]pyridines,”Tetrahedron Letters, 47 (35), pp. 6235-6238, (2006).
Heindel et al., “Salicylidene-thiolactone Rearrangement. A Direct Synthesis of 4H-2-Arylthieno [3,2-c] [1] benzopyran-4-ones,”J. Org. Chem. 42(8), pp. 1465-1466, (1977).
Katsura et al., “Anti-Helicobacter pyloriAgents. 4. 2-(Substituted guanidino)-4-phenylthiazoles and Some Structurally Rigid derivatives,”J. Med. Chem. 43 (17), pp. 3315-3321, (2000).
Majumdar et al., “Regioselective Synthesis of Thieno[3,2-c] [1] benzopyran-4-ones by Thio-Claisen Rearrangement,”Monatshefte fur Chemie135(8), pp. 1001-1007, (2004).
Navarro et al., “Synthesis of 1H-[1] Benzopyrano [4,3-b] Pyrrole and 4H-thieno [3,2-c] Benzopyran Derivatives, functionalisation by Aromatic Electrophilic substitution,”Heterocycles, 55 (12), pp. 2369-2386, (2001).
Potts et al., “Carbon-Carbon Bond Formation via Intramolecular Cycloadditions: Use of the Thiocarbonyl Ylide Dipole inanhydro-4-Hydroxythiazolium Hydroxides,” ,J. Org. Chem. 54, pp. 1077-1088, (1989).
Potts et al., “Intramolecular 1, 3-Dipolar Cycloadditions with Thiocarbonyl Ylides,”J. Chem. Soc., Chem. Commun., 7, pp. 561-563, (1986).
Reiter et al., “Pyrimidine benzamide-based thrombopoietin receptor agonists,”Bioorganic&Medicinal Chemistry Letters, 17 (19) pp. 5447-5454, (2007).
Rueeger et al., “Discovery and SAR of potent, orally available and brain-penetrable 5,6-dihydro-4H-3-thia-1-aza-benzo[e]azulen-derivatives as neuropeptide Y Y5 receptor antagonists,”Bioorganic&Medicinal Chem. Letters, 14 (10), pp. 2451-2457, (2004).
Sekhar et al., “A Simple and Convenient Method for the Synthesis of Condensed Thiophene Derivatives Starting from Heterocyclic Chloro Aldehydes. Part II,”Sulfur Letters, 9 (6), pp. 271-277, (1989).
Trieu et al., “The Condensation (beta-chlorovinyl) Carbonyl Compounds with alpha-mercaptocarboxylic acids (translated from German),”Zeitschrift fuer Chemie, (translated from German), 13 (2), pp. 57-58, (1973).


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