Benzopyran and benzoxazine derivatives

Details Benzopyran and benzoxazine derivatives Benzopyran and benzoxazine derivatives

1998-02-19

1999-11-02

Fan, Jane

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

549400, 549404, A61K 3135

Patent

active

059771674

ABSTRACT:
Novel benzopyran and benzoxazine derivatives represented by the general formula: wherein R.sub.1 and R.sub.2 represent a lower haloalkyl group, R.sub.3 represents a hydrogen atom, etc., R.sub.4 represents a heterocyclic group or A--O-- wherein A represents a cyclic structure, etc., R.sub.5 and R.sub.6 represent a lower haloalkyl, X represents .dbd.N--, N.fwdarw.O, etc, are disclosed. These compounds exhibit K.sup.+ channel opening activating and can be widely used as an anti-asthma drug, an anti-epilepsy drug, etc.

REFERENCES:
patent: 3046300 (1962-07-01), Sletzinger
Buckle et al., "A Novel, Potent Airway-Selective Potassium Channel Activator," Biorganic & Medical Chemistry Letters, vol. 2, No. 9, pp. 1161-1164. 1992.
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Buckle et al., "Relaxant Activity of 4-Amino-3,44-dihydro-2H-1-Benzopyran-3-ols . . . Trachealis," J. Med. Chem. vol. 33, pp. 3028-3034, 1990.
Evans et al., Synthesis and Antihypertensive of Substitute trans-4-Amino-3, . . . 3-ols, J. Med. Chem., vol. 26, pp. 1582-1589, 1983.
Ashwood et al., "Synthesis and Antihypertension Activity of 4-(Cyclic Amindo) . . . Benzyopyrans," J. Med. Chem. vol. 29, pp. 2194-2201, 1986.
Pinder et al., Journal of Pharmaceutical Sciences, vol. 56, No. 8, pp. 970-973, Aug. 1967.
Topliss, Journal of Medical Chemistry, 1972, vol. 15, No. 10, pp. 1006-1010 .

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