Benzopyran and benzo-fused compounds, their preparation and thei

Details Benzopyran and benzo-fused compounds, their preparation and thei Benzopyran and benzo-fused compounds, their preparation and thei

1999-02-01

2000-09-12

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514269, 514278, 514311, 514314, 514307, 544333, 544405, 546 18, 546145, 546165, A61K 3147, A61K 314709, C07D215233, C07D40104, C07D40106

Patent

active

061178748

ABSTRACT:
This invention relates to novel benzopyran and other benzo-fused leukotriene B.sub.4 (LTB.sub.4) antagonists and the pharmaceutically acceptable salts thereof, to pharmaceutical compositions containing such compounds, and to a method of using such compounds as LTB.sub.4 antagonists. The compounds of this invention inhibit the action of LTB.sub.4 and are therefore useful in the treatment of LTB.sub.4 induced illnesses such as inflammatory disorders including rheumatoid arthritis, osteoarthritis, inflammatory bowel disease, psoriasis and other skin disorders such as eczema, erythema, pruritus and acne, stroke and other forms of reperfusion injury, graft rejection, autoimmune diseases, asthma, and other conditions where marked neutrophil infiltration occurs.

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