Benzophenones

Details Benzophenones Benzophenones

1984-06-07

1985-06-11

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

560107, 560 52, 560 21, 560 10, 564169, 2605011, 26050113, 260465F, 548228, C07C 6532

Patent

active

045230307

ABSTRACT:
Substituted benzophenones of the formula ##STR1## in which Ph represents unsubstituted or substituted phenyl and R represents free, esterified or amidated carboxy, have anti-inflammatory and/or analgesic properties and can be used as active ingredients in medicaments. They are manufactured, for example, as follows:
a compound or a mixture of compounds of the formula ##STR2## in which X.sub.1 and X.sub.2 together represent a group of the formula --C(.dbd.O)--O that is bonded via the carbonyl group to the radical Ph and X.sub.3 represents hydrogen, or one of the radicals X.sub.1 and X.sub.3 represents a group of the formula --C(.dbd.O)--Z, the other represents hydrogen and X.sub.2 represents a group R'O-- in which R' represents hydrogen or a hydroxy-protecting group, is subjected to acid treatment and the primary product is decomposed solvolytically.

REFERENCES:
patent: 3953500 (1976-04-01), Noguchi et al.
patent: 4057573 (1977-11-01), Haas et al.
patent: 4272547 (1981-06-01), Haas et al.

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