Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal
Patent
1978-07-31
1981-01-06
Phillips, Delbert K.
Chemistry of carbon compounds
Miscellaneous organic carbon compounds
C-metal
C07C10352
Patent
active
RE0304735
ABSTRACT:
This invention is directed toward pharmacologically active compounds of the formula ##STR1## wherein A represents a nitrogen atom which may be substituted by a methyl, cyclopropylmethyl, di(C.sub.1-4 alkyl)aminoethyl, methoxymethyl or hydroxyethyl group and B represents a carbonyl group or A and B together represent a grouping of the formula ##STR2## in which R.sup.a represents a hydrogen or a lower alkyl or hydroxymethyl group and X represents a nitrogen atom or C-R.sup.b wherein R.sup.b represents a hydrogen atom or a lower alkyl or hydroxymethyl group; R represents a halogen atom or a nitro or trifluoromethyl group; R.sup.1 represents a hydrogen atom or a lower alkyl group; R.sup.2 represents an acyl group derived from a naturally occurring amino acid (all such groups which contain an asymmetric carbon atom having the L- or D,L-configuration) and R.sup.3 represents a phenyl, halophenyl or 2-pyridyl group and acid addition salts thereof.
Also provided are methods for their preparation and intermediates thereof. These compounds exhibit activity as anticonvulsants, muscle relaxants and sedatives.
REFERENCES:
patent: 3674787 (1972-07-01), Frey et al.
patent: 3772371 (1973-11-01), Tachikawa et al.
patent: 3883591 (1973-05-01), McCaully
patent: 3931314 (1976-01-01), Greve et al.
CIBA, CA 56:3562g (1962).
Hassall Cedric H.
Johnson William H.
Krohn Antonin
Smithen Carey E.
Thomas William A.
Hoffman Frank P.
Hoffmann-La Roche Inc.
Leon Bernard S.
Phillips Delbert K.
Saxe Jon S.
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