Benzophenone derivatives useful in treating heart failure

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Recombinant or stably-transformed bacterium encoding one or...

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424327, 564195, 564220, 564256, 564266, C07C13100, C07C10344, A61K 31165

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active

044724357

ABSTRACT:
There is presented novel benzophenone derivatives of the formula ##STR1## wherein R.sup.1 is hydrogen or lower alkyl, R.sup.2 is hydrogen or aminoacetyl, R.sup.3 is hydrogen or lower alkyl, R.sup.4 is hydrogen or halogen, R.sup.5 is hydrogen, amino, nitro or a group of the formula R.sup.3 --ON.dbd.C(R.sup.6)--and R.sup.6 is lower alkyl, with the proviso that R.sup.5 is a group of the formula H--ON.dbd.C(R.sup.6)--when R.sup.2 and R.sup.3 are both hydrogen, and their pharmaceutically acceptable acid addition salts.
The compounds exhibit aldosterone-antagonistic properties and are accordingly suitable for the control or prevention of heart failure, hepatic ascites, primary aldosteronism and idiopathic hypertension.

REFERENCES:
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patent: 3202699 (1965-08-01), Stempel
patent: 3465038 (1969-09-01), Dolan
patent: 3513191 (1970-05-01), Bell
patent: 3887604 (1975-06-01), Archer et al.
patent: 4022832 (1977-05-01), Tachikawa et al.

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