Benzonitrile and benzothiocyano intermediates

Details Benzonitrile and benzothiocyano intermediates Benzonitrile and benzothiocyano intermediates

1983-10-19

1986-06-17

Hollrah, Glennon H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitriles

578253, 578251, 558413, 558 13, C07C12176, C07C16102

Patent

active

045955409

ABSTRACT:
There are described compounds of the formula ##STR1## in which R.sup.1 is hydrogen or C.sub.1-6 alkyl, R.sup.2 is hydrogen, C.sub.1-6 alkyl or C.sub.3-6 alkenyl, X and Y are each oxygen, sulphur, sulphinyl or sulphonyl, n is 2 to 6 and Z is 1H-tetrazol-5-yl, 1H-tetrazol-5-ylthio, 1H-tetrazol-5-ylsulphinyl, 1H-tetrazol-5-ylsulphonyl, cyano or thiocyano, provided that when both X and Y are oxygen Z is 1H-tetrazol-5-ylthio, 1H-tetrazol-5-ylsulphinyl, 1H-tetrazol-5-ylsulphonyl or thiocyano; and salts thereof. The compounds in which Z is other than cyano or thiocyano have pharmaceutical activity and inhibit leukotriene action or formation. '

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