Benzonaphthalene derivatives and their use in therapeutic and co

Details Benzonaphthalene derivatives and their use in therapeutic and co Benzonaphthalene derivatives and their use in therapeutic and co

1992-07-10

1994-12-06

Higel, Floyd D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 42, 514 43, 514 63, 5142375, 514255, 514319, 514423, 514532, 514533, 514543, 514546, 514547, 514548, 514549, 514550, 514551, 514569, 514617, 514618, 514621, 514622, 514730, 514859, 514863, 514880, 514885, 514886, 514887, 514912, 536 187, 536 221, 536 291, 544 64, 544176, 544225, 544391, 546 14, 546205, 548406, 548539, 556419, 556437, 556449, 560 56, 560 89, 560 90, 560 91, 560100, 560194, 560250, 560251, 560252, 560255, 562467, 562490, 564162, 564169, 564172, 564173, 568808, A61K 31045, A61K 31085, A61K

Patent

active

RE0348058

ABSTRACT:
A benzonaphthalene compound has the formula ##STR1## wherein R.sub.1 represents ##STR2## or (ii) --CH.sub.2 OH; R.sub.6 represents ##STR3## or OR.sub.7 wherein R.sub.7 represents hydrogen, alkyl having 1-20 carbon atoms, monohydroxyalkyl or polyhydroxyalkyl, r' or r" represent hydrogen, lower alkyl, mono or polyhydroxyalkyl, aryl or a residue of an amino acid or a sugar, or together form a heterocycle; R.sub.2 represents hydrogen, alkyl having 1-15 carbon atoms, alkoxy having 1-4 carbon atoms or a cycloaliphatic radical; R.sub.3 represents hydrogen, hydroxy, alkyl having 1-4 carbon atoms, alkoxy having 1-10 carbon atoms, a cycloaliphatic radical, a thiocycloaliphatic radical or --O--Si(CH.sub.3).sub.2 --R.sub.8 wherein R.sub.8 represents lower alkyl; and R.sub.4 and R.sub.5 represent hydrogen, lower alkyl, hydroxy or lower acyloxy.
This compound is useful in the topical and systemic treatment of dermatologic diseases and in the treatment of the degeneration of conjunctive tissues. The compound also possesses anti-tumor acitivity.

REFERENCES:
Chem. Abstracts; vol. 103; 160190k (1985).

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