Benzonaphthalene derivatives, a process for their preparation an

Details Benzonaphthalene derivatives, a process for their preparation an Benzonaphthalene derivatives, a process for their preparation an

1990-03-30

1992-03-24

Richter, Johann

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 63, 5142375, 514255, 514319, 514844, 514845, 514859, 514863, 514913, 514914, 514533, 514544, 514559, 514569, 514617, 514618, 514619, 514620, 514621, 514622, 514682, 514700, 514712, 514717, 514718, 514719, 514721, 514730, A61K 31435, B01J 2904, B01J 2906

Patent

active

050988956

ABSTRACT:
A benzonaphthalene compound has the formula ##STR1## wherein R.sub.1 represents ##STR2## or (ii) --CH.sub.2 OH; R.sub.6 represents ##STR3## or OR.sub.7 wherein R.sub.7 represents hydrogen, alkyl having 1-20 carbon atoms, monohydroxyalkyl or polyhydroxyalkyl, r' or r" represent hydrogen, lower alkyl, mono or polyhydroxyalkyl, aryl or a residue of an amino acid or a sugar, or together form a heterocycle; R.sub.2 represents hydrogen, alkyl having 1-15 carbon atoms, alkoxy having 1-4 carbon atoms or a cycloaliphatic radial; R.sub.3 represents hydrogen, hydroxy, alkyl having 1-4 carbon atoms, alkoxy having 1-10 carbon atoms, a cycloaliphatic radical, a thiocycloaliphatic radical or --O--Si(CH.sub.3).sub.2 --R.sub.8 wherein R.sub.8 represents lower alkyl; and R.sub.4 and R.sub.5 represent hydrogen, lower alkyl, hydroxy or lower acyloxy.
This compound is useful in the topical and systemic treatment of dermatologic diseases and in the treatment of the degeneration of conjunctive tissues. The compound also possesses anti-tumor activity.

REFERENCES:
patent: 4940696 (1990-07-01), Shroot et al.

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