Benzonaphthacene glycoside derivative and use thereof

Details Benzonaphthacene glycoside derivative and use thereof Benzonaphthacene glycoside derivative and use thereof

2005-09-05

2010-06-08

Jiang, Shaojia Anna (Department: 1623)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C536S016800, C514S033000

Reexamination Certificate

active

07732582

ABSTRACT:
A dicarboxylic acid compound obtainable by oxidative degradation of pradimicin antibiotics, which are antibiotics consisting of the benzonaphthacene skeleton, a D-amino acid side chain and a sugar chain, for the second saccharide residue of the sugar chain, and use thereof utilizing a specific microorganism binding property thereof are provided. The dicarboxylic acid compound has significantly improved water-solubility compared with the raw material antibiotics, whist maintaining the specific microorganism binding property.

REFERENCES:
patent: 2000-1497 (2000-01-01), None
Berge et al. Journal of Pharmaceutical Science, 1977, 66(1), p. 1-19.
Ueki et al. Journal of Antibiotics, 1993, 46(3), p. 455-464.
Toshikazu Oki, Protein, Nucleic acid and Enzyme, May 1994, vol. 39, No. 6, pp. 973-978.
Karlowsky, J. A. et al., In Vitro Antifungal Activity of BMS-181184 against Systemic Isolates of Canada, Cryptococcus, and Blastomyces Species, Diagnostic Microbiology and Infectious Disease, 1997, vol. 28, No. 4, pp. 179 to 182.
Aburaki et al., The Journal of Antibiotics, Apr. 1993, vol. 46, No. 4, pp. 631-640.

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