Benzoic acid derivatives, processes for the preparation...

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C546S297000, C546S312000

Reexamination Certificate

active

10737901

ABSTRACT:
An agent comprising the benzoic acid of formula (I)wherein A, B, R6, R7are carbocyclic ring, heterocyclic ring, etc.; R1is hydroxy etc.; R2, R3, R4are alkyl etc.; R5, D, E are alkylene, etc.; G is oxygen etc., as active ingredient.The compound of formula (I) is considered to be useful for the treatment and/or prophylaxis of bone diseases, cancer, systemic granuloma, immunological diseases, allergy, atopy, asthma, gumboil, gingivitis, periodontitis, neurocyte death, Alzheimer's diseases, lungs injury, pulmopathy, acute hepatitis, nephritis, myocardial ischemia, Kawasaki disease, ambustion, ulcerative colitis, Crohn's disease, multiple organ failure, sleeping disorder, platelet aggregation, etc.

REFERENCES:
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patent: 1 500 839 (1978-02-01), None
patent: WO 95/33458 (1995-12-01), None
Miyaura, J of Biological Chemistry, vol. 275, No. 26, Jun. 2000, pp. 19819-19828.
Fedyk, Porc Natl Acad Sci USA, vol. 93, pp. 10978-10983, Oct. 1996.
Bazan, Prostagladins & Other Lipid Mediators, 68-69, 2002, pp. 197-210.
Cazin, CA 112:191376, Abstract of FFarmaco, vol. 44 (7-8), pp. 683-694 (1989).

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