Benzoic acid derivatives

Details Benzoic acid derivatives Benzoic acid derivatives

1985-10-18

1987-10-06

Lone, Werren B.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

514576, 514616, 560 11, 560 12, 560 18, 562429, 562430, 562431, 562432, 564154, A61K 3110, A61K 31165, C07C14940, C07C14941

Patent

active

046983643

ABSTRACT:
Benzoic acid derivatives of the formula: ##STR1## wherein n is an integer of 0 to 2; R.sub.1 to R.sub.3 which may be the same or different each represents a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group or nitro group; R.sub.4 is a hydroxyl group or the group --NHZ (Z is hydrogen atom or a lower alkyl group), or an alkali metal salts thereof are useful as an infection control agent.
These derivatives excepting compounds of the formula above wherein n is 0 or 1; any one of R.sub.1 to R.sub.3 is 5-chloro, 5-methoxy or 5-nitro and the remainder is a hydrogen atom; and R.sub.4 is a hydroxyl group; and compounds of the formula wherein n is 0 or 1; two of R.sub.1 to R.sub.3 are 3,5-dichloro or 3,5-dinitro and the remainder is a hydrogen atom; and R.sub.4 is a hydroxy group) are novel, and they were first prepared in this invention.

REFERENCES:
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patent: 3514480 (1970-05-01), Fields
patent: 3657431 (1972-04-01), Shen et al.
Chemical Abstracts, vol. 54, No. 10, 5/25/60, col. 9815, abstract c, Columbus, Ohio US, F. Gialdi et al "2,2'-Dicarbamidodiphenyl Sulfides and Sulfones", & Farmaco (Pavia) ed. Sci.14 830-44 (1959).
Tetrahedron, vol. 35, 1979, pp. 1869-1874, Pergmon Press Ltd., Oxford BG; I. Kapovits et al "Diaryldiacyloxyspirosulfuranes.I Halogenating Agents" * Formulas 2a-2c,2e,2j-2k, p. 1872, right-hand col. p. 1873.
Tetrahedron, vol. 35, 1979, pp. 1875-1881, Pergamon Press Ltd., Oxford GB; I. Kapovits et al: "Diaryldiacyloxyspirosulfuranes.I.I Syntheses from Sulfoxides and Hydrolysis" * Formulas 2a-2c, 2e,2j-2k.
Journal of the American Chemical Society, vol. 100, No. 3, Feb. 1st 1978, pp. 953-962, American Chemical Society, Easton US, L. J. Adzima et al: "Synthesis, Reactions, and Crystal and Molecular Structure . . . ".
Journal of the Chemical Society, Perkin Transactions 1, 1979, pp. 799-802, J. Grimshaw et al: "Electrochemical Reactions, Part 22, Intramolecular Trapping of Radical Intermediates in the Reduction of Arylsulphones".

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