Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1996-11-13
2000-08-01
Shah, Mukund J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
540571, 540593, C07D22316, C07D24312, A61K 3147, A61K 3155
Patent
active
060967358
DESCRIPTION:
BRIEF SUMMARY
TECHNICAL FIELD
The present invention relates to novel benzoheterocyclic derivatives having excellent vasopressin antagonistic activities, vasopressin agonistic activities and oxytocin antagonistic activities.
BACKGROUND ART
Various benzoheterocyclic compounds analogous to the compounds of the present invention have been known to have anti-vasopressin activities in European Patent Publication No. 0382128 (published on Aug. 15, 1990), WO 91/05549 (published on May 2, 1991), WO 91/16916 (published on Nov. 14, 1991), WO 94/08582 (published on Apr. 28, 1994), WO 94/12476 (published on Jun. 9, 1994), JP-A-5-320135 (published on Dec. 3, 1993), JP-A-6-16643 (published on Jan. 25, 1994), and JP-A-6-157480 (published on Jun. 3, 1994), among which, for example, JP-A-6-16643 discloses the following compounds. ##STR2##
Some other literatures disclose various benzoheterocyclic compounds which are analogous to the compounds of the present invention in the chemical structure but are different in the pharmacological properties. For example, EP-A-294647 discloses some analogous compounds having positive inotropic action, vasodilating activity and platelet agglutination inhibiting activity, wherein the intermediate compounds of the following formula are also disclosed. ##STR3##
U.S. Pat. Nos. 3,542,760 (issued Nov. 24, 1970), 3,516,987 (issued Jun. 23, 1970) and 3,458,498 (issued Jul. 29, 1969) disclose also the following compounds which are useful as diuretics, hypoglycemics, antibacterials or anti-convulsants. ##STR4##
J. Chem. Soc. Perkin Trans., 1, 1985, pp. 1381-1385 discloses the following compounds but does not mention any pharmacological activity thereof. ##STR5##
DISCLOSURE OF INVENTION
An object of the present invention is to provide a benzoheterocyclic derivative of the following formula [1]: ##STR6## wherein G is a group of the formula: ##STR7## or a group of the formula: ##STR8## R.sup.1 is a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group, a hydroxy group, a lower alkanoyloxy group, an amino-lower alkoxy group having optionally a substituent selected from a lower alkyl group and a lower alkanoyl group, an amino group having optionally a lower alkyl substituent, a carboxy-substituted lower alkoxy group, a lower alkoxycarbonyl-substituted lower alkoxy group, or an aminocarbonyl-lower alkoxy group having optionally a lower alkyl substituent, R.sup.5 are the same or different, and each a hydrogen atom, a lower alkyl group having optionally a hydroxy substituent or a benzoyl group having optionally a halogen substituent on the phenyl ring); a hydrogen atom; a hydroxy group; a lower alkoxy group; a carboxy-substituted lower alkyl group; a cyano-substituted lower alkyl group; a tetrazolyl-substituted lower alkyl group; a lower alkanoyloxy-substituted lower alkyl group; a lower alkoxycarbonyl-substituted lower alkyl group; an amino-substituted lower alkanoyloxy group having optionally a lower alkyl substituent; a lower alkoxycarbonyl-substituted lower alkoxy group; a carboxy-substituted lower alkoxy group; a lower alkanoyl group; or a group of the formula: --(O).sub.m --A--(CO).sub.u NR.sup.6 R.sup.7 (in which m and u are each 0 or 1, but both m and n should not be simultaneously 0, A is a lower alkylene group, R.sup.6 and R.sup.7 are the same or different and each a hydrogen atom, a lower alkoxy group, a lower alkyl group, an amino-substituted lower alkyl group having optionally a lower alkyl substituent, a carbamoyl-substituted lower alkyl group, an adamantyl-substituted lower alkyl group, a lower alkylsulfonyl group, or a phenyl group having optionally a halogen substituent, or R.sup.6 and R.sup.7 may bind together with the nitrogen atom to which they bond to form a 5- to 7-membered saturated heterocyclic group with or without being intervened with another nitrogen atom or an oxygen atom, said heterocyclic group being optionally substituted by a lower alkyl group or a phenyl-lower alkyl group), alkylidene group, a lower alkoxy-substituted lower alkylidene group, a lower alkoxycarbony
REFERENCES:
patent: 5244898 (1993-09-01), Ogawa et al.
patent: 5258510 (1993-11-01), Ogawa et al.
patent: 5498609 (1996-03-01), Ogawa et al.
patent: 5559230 (1996-09-01), Ogawa et al.
patent: 5622947 (1997-04-01), Ogawa et al.
patent: 5753644 (1998-05-01), Ogawa et al.
patent: 5753677 (1998-05-01), Ogawa
Kan Keizo
Kondo Kazumi
Kurimura Muneaki
Matsuzaki Takayuki
Ogawa Hidenori
Kifle Bruck
Otsuka Pharmaceutical Company Limited
Shah Mukund J.
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