Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1988-04-08
1997-01-07
Dentz, Bernard
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
5142315, 514249, 514312, 544128, 544349, 544363, 546156, A61K 3147, C07D40104
Patent
active
055917445
ABSTRACT:
Novel 4-oxoquinoline-3-carboxylic acid compounds of the formula: ##STR1## wherein R.sup.1 is cyclopropyl which may have 1 to 3 substituents of alkyl and halogen; phenyl which may be substituted by 1 to 3 substituents of alkoxy, halogen and OH; alkyl which may be substituted by halogen, alkanoyloxy or OH; alkenyl; or thienyl, R.sup.2 is 5- to 9-membered saturated or unsaturated heterocyclic ring which may be sustituted, R.sup.3 is alkyl or halogen, R.sup.4 is alkyl or halogen, R is H or alkyl, R.sup.1 and R.sup.3 may be taken together to form ##STR2## wherein R.sup.31 is H or alkyl, and X is halogen, provided that R.sup.3 and R.sup.4 are not simultaneously halogen, and salts thereof, said compounds having excellent antimicrobial activity and hence being useful as an antimicrobial agent, and a pharmaceutical composition containing said compound as an active ingredient.
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Miyamoto Hisashi
Tone Hitoshi
Ueda Hiraki
Yamashita Hiroshi
Dentz Bernard
Otsuka Pharmaceutical Company Limited
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