Benzoheterocyclic compounds

Details Benzoheterocyclic compounds Benzoheterocyclic compounds

1988-10-17

1990-06-19

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

544128, A61K 31535, C07D41304

Patent

active

049354205

ABSTRACT:
Novel 4-oxoquinoline-3-carboxylic acid compounds of the formula: ##STR1## wherein R.sup.2 is a morpholino group which may be substituted by one to three C.sub.1 -C.sub.6 alkyl groups where each of the alkyl group may be substituted by 1 to 3 substituents selected from the group consisting of --NH.sub.2 and a halogen atom, and R.sup.3 is a C.sub.1 -C.sub.6 alkyl, --CH.sub.2 OH, ##STR2## (C.sub.1 -C.sub.6)alkylthiomethyl and --CH.sub.2 -halogen, or a pharmaceutically acceptable salt thereof, said compounds having excellent antimicrobial activity and hence being useful as an antimicrobial agent, and a pharmaceutical composition containing said compound as an active ingredient.

REFERENCES:
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patent: 4556658 (1985-12-01), Grohe et al.
patent: 4563459 (1986-01-01), Grohe et al.
patent: 4705788 (1987-11-01), Shriewer et al.
"Chemical Abstracts", vol. 109, 1988, Col. 109:37744r.
Research Disclosure 269008, "Use of Gyrase Inhibitors for Treating Infections by Rectal or Vaginal Administration", (Sep. 1986).
Research Disclosure 26924, "Use of Gyrase Inhibitors in Aerosol Form for Treating Respiratory Infections", (Sep., 1986).

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