Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1992-04-17
1993-09-14
Shah, Mukund J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
540593, A61K 3155, C07D22316
Patent
active
052448983
ABSTRACT:
Novel benzoheterocyclic compounds of the formula: ##STR1## wherein R.sup.1 is H, halogen, OH, etc,; R.sup.2 is H, alkyl, halogen or alkoxy; R.sup.3 is phenyl-alkanoylamino, or ##STR2## R.sup.4 is H, --NR.sup.6 R.sup.7, alkenyloxy, HO-alkyl, --O--CO--A--NR.sup.8 R.sup.9, etc.; R.sup.5 is H, OH, etc., or a salt thereof, which have excellent vasopressin antagonistic activities and useful as vasodilator, hypotensive agent, water diuretics, platelet agglutination inhibitor, and a vasopressin antagonistic composition containing the compound as the active ingredient.
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Chemical Abstracts, 81:450 (Abstract No. 77786r) 1974.
Chemical Abstracts, 102:17 (Abstract No. 143336z) 1985.
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Okada et al, Biochem. Biophys. Res. Comm., 178:707-712 (1991).
Kitano Kazuyoshi
Komatsu Hajime
Kondo Kazumi
Nakaya Kenji
Ogawa Hidenori
Otsuka Pharmaceutical Co. Ltd.
Shah Mukund J.
Ward E. C.
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