Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1997-02-13
2000-08-29
Dees, Jose' G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514320, 514321, 514315, 514249, 514319, 514322, 514328, 514338, 514258, 546159, 546193, 546194, 546199, 544336, 544349, A61K 31445, A61K 3143, C07D21100, C07D24100
Patent
active
061109355
ABSTRACT:
Compounds of the general structural formula ##STR1## are shown to have AMPA receptor enhancing properties. The compounds are useful for such therapeutic purposes as facilitating the learning of behaviors dependent upon AMPA receptors, and in treating conditions, such as memory impairment, in which AMPA receptors, or synapses utilizing these receptors, are reduced in numbers or efficiency. They may also be used to enhance excitatory synaptic activity in order to restore an imbalance between brain subregions, as in treatment of schizophrenia or schizophreniform behavior.
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Marrs Christopher M.
Rogers Gary A.
Coleman Henry D.
Dees Jos,e G.
Qazi Sabiha N.
Sudol R. Neil
The Regents of the University of California
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