Benzofuranylimidazole derivatives and therapeutical compositions

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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5483114, A61K 31415, C07D40504

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active

053547691

ABSTRACT:
The invention relates to benzofuranylimidazole derivatives of the general formula (1) ##STR1## wherein R.sub.1 and R.sub.2 represent various radicals, to a process for their preparation and to pharmaceutical compositions containing them.

REFERENCES:
patent: 3927023 (1975-12-01), Brown et al.
patent: 4510159 (1985-04-01), Cozzi et al.
patent: 4950681 (1990-08-01), Cavalla et al.
patent: 4985440 (1991-01-01), Cozzi et al.
Shridhar et al., "Benzofuran Derivatives: Part II-Synthesis & Biological Activity of Some New 2-Benzofurancarboxamidine Derivatives", Indian Journal of Chemistry, vol. 18B., Sep. 1979, pp. 254-256.
Langin et al., "Binding of [.sup.3 H]Idazoxan and of Its Methoxy Derivative [.sup.3 H]RX821002 in Human Fat Cells: [.sup.3 H]Idazoxan but Not [.sup.3 H]RX821002 Labels additional Non-a.sub.2 -Adrenergic Binding Sites", Molecular Pharm. 37:876-885 (1990).
Bousquet et al., "New Concepts on the Central Regulation of Blood Pressure", The American Journal of Medicine, vol. 87, Sep. 1989, pp. 3C-10S-3C-13S.
Gothert et al., "Involvement of presynaptic imidazoline receptors in the a.sub.2 -adrenoceptor-independent inhibition of noradrenaline release by imidazoline derivatives", Arch. Pharmacol. (1991) 343:271-282.
S. Tanaka, "Coumarones from o-Hydroxyaldehydes and Bromoalonic Ester", J. Am. Chem. Soc. (1951) 73:872.
Jackson et al., "The effects of idazoxan and other a.sub.2 -adrenoceptor antagonists on food and water intake in the rat", Br. J. Pharmacol. (1991) 104:258-262.
Chapleo et al., "a-Adrenoreceptor Reagents [etc]", J. Med. Chem. 1984, 27, 570-576.

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