Benzofuran derivatives, their production and use

Details Benzofuran derivatives, their production and use Benzofuran derivatives, their production and use

2006-09-05

2006-09-05

Raymond, Richard L. (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S416000, C514S414000, C514S469000, C514S225200, C548S454000, C549S469000, C549S467000, C549S491000

Reexamination Certificate

active

07101867

ABSTRACT:
Compounds represented by the formula:wherein R1and R2are hydrogen atom, a hydrocarbon group or a heterocyclic group, or R1and R2may form, together with the adjacent carbon atom, a 3- to 8-membered homocyclic or heterocyclic ring,W indicates(i) a group represented by the formula:wherein ring B indicates a 5- to 7-membered ring, or(ii) a group represented by the formula:wherein R4indicates (1) an aliphatic hydrocarbon group, which may be substituted with an aromatic group, or (2) an acyl group containing an aromatic group, R5is hydrogen atom, a C1-6alkyl, or an acyl group, provided that, when W is Wa, R3is hydrogen atom, a hydrocarbon group or a heterocyclic group, when W is Wb, R3indicates a C6-14aryl group, or salts thereof or prodrugs thereof have an excellent action to inhibit neurodegeneration and the like as well as an excellent brain penetrability and are low in the toxicity, thereby being useful as prophylactic or therapeutic drugs for nerve degenerative diseases and the like.

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