Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1988-03-18
1989-07-04
Schwartz, Richard A.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514255, 514269, 514318, 514320, 514378, 514406, 514422, 514444, 514469, 544122, 544124, 544131, 544137, 544140, 544141, 544146, 544153, 544295, 544333, 544360, 544367, 544371, 544372, 544379, 546194, 546196, 546269, 548247, 548374, 548518, 548525, 549 60, 549471, A61K 31445, C07D40514
Patent
active
048450960
ABSTRACT:
Benzofuran derivatives of the general formula I ##STR1## where R.sup.1 and R.sup.2 are each hydrogen, alkyl or phenylalkyl, where alkyl in each case is of 1 to 4 carbon atoms, R.sup.3 and R.sup.4 are identical or different and are each hydrogen or C.sub.1 -C.sub.4 -alkyl or together form a 3-membered to 5-membered chain which may be interrupted by an oxygen atom or an NR.sup.1 group, X is --CO--CH.dbd.CH--, --CO--CH.sub.2 --CH.sub.2 --or --CHOH--CH.sub.2 --CH.sub.2 --, n is 2 or 3 and Het is an aromatic 5-membered or 6-membered ring which contains a hetero atom from the group consisting of N, O and S and may additionally contain a (further) N atom, in which the ring may be substituted by C.sub.1 -C.sub.4 -alkyl, fluorine, chlorine, bromine, NH.sub.2 or NR.sup.1 R.sup.2, where R.sup.1 and R.sup.2 have the abovementioned meanings, the use of these benzofuran derivatives for the preparation of pharmaceutical, in particular antiulcerogenic, agents, and these agents themselves are described.
REFERENCES:
patent: 3631034 (1971-12-01), Fauran et al.
patent: 3658822 (1972-04-01), Fauran et al.
patent: 3850937 (1974-12-01), Fauran et al.
patent: 3862176 (1975-01-01), Fauran et al.
patent: 4153620 (1970-05-01), Bourgery et al.
Chemical Abstract (1974) 81(17):99 240k.
Chemical Abstract (1974) 81(9):45196g.
European Journal of Medicinal Chemistry--Chimica Therapeutica--EDIFOR Pub. Office, Paris, vol. 9 (1974) pp. 85-93.
Ruebsamen Klaus
Schlecker Rainer
BASF Aktiengsellschaft
Dentz Bernard J.
Schwartz Richard A.
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