Benzofuran derivatives

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514450, 514452, 514464, 514468, 549299, C07D30777, A61K 3134

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active

050666690

ABSTRACT:
A novel biphenyl derivative of the formula: ##STR1## wherein Ring A is a substituted or unsubstituted sulfur-containing or oxygen-containing heteromonocyclic ring; Ring B is a ring of the formula: ##STR2## each of R.sup.1 and R.sup.3 is hydrogen atom, a halogen atom or a lower alkoxy group, or R.sup.1 is hydrogen atom, and R.sup.2 and R.sub.3 are combined together to form a lower alkylenedioxy group; R.sup.4 is a lower alkyl group which may have a substituent selected from a lower alkoxy group and a lower alkoxycarbonyl group; Y is methylene group or carbonyl group, and a pharmaceutically acceptable salt thereof are disclosed. Said derivative and a pharmaceutically acceptable salt thereof are useful as a therapeutic or prophylactic agent for hepatic diseases.

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Synthesis of ENOL Lactones of 3-Aroyl-2-(Thienylmethylene)-Propionic Acids . . . , N. R. Guirguis et al., Liebigs Ann. Chem., 1986, (6) 1003-1011 [C.A. 105:42581g].
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