Benzofuran derivative

Details Benzofuran derivative Benzofuran derivative

2008-01-01

2008-01-01

Habte, Kahsay (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C544S238000

Reexamination Certificate

active

10547779

ABSTRACT:
The present invention is directed to a compound represented by formula (1):(wherein R1represents an alkyl group which may have a substituent or an alkenyl group which may have a substituent; andeach of R2and R3represents a hydrogen atom, an alkyl group, a hydroxyalkyl group, a dihydroxyalkyl group, or an alkynyl group, or R2and R3form, together with the nitrogen atom adjacent thereto, a nitrogen-containing saturated heterocyclic group which may have a substituent) and a drug composition containing the compound. The compound exhibits tumor necrosis factor (TNF-α) production inhibitory effect and improved absorption upon oral administration.

REFERENCES:
patent: 6348468 (2002-02-01), Ohkuchi et al.
patent: 6403586 (2002-06-01), Ohkuchi et al.
patent: 6664256 (2003-12-01), Ohkuchi et al.
patent: 6680316 (2004-01-01), Ohkuchi et al.
patent: 6861428 (2005-03-01), Kyotani et al.
patent: 6869954 (2005-03-01), Kyotani et al.
patent: 2002/0123496 (2002-09-01), Ohkuchi et al.
patent: 2004/0147516 (2004-07-01), Ohkuchi et al.
patent: 2005/0065155 (2005-03-01), Ohkuchi et al.
patent: 2005/0085480 (2005-04-01), Kyotani et al.
patent: 0 611 815 (1994-08-01), None
patent: 0 926 137 (1999-06-01), None
patent: 2000-290261 (2000-10-01), None
patent: 2001-151779 (2001-06-01), None
patent: 2001-151780 (2001-06-01), None
patent: 2001-158789 (2001-06-01), None
patent: 2001-511764 (2001-08-01), None
patent: 2005-14808 (2005-01-01), None
patent: 01/22966 (2001-04-01), None
patent: 01/58900 (2001-08-01), None
patent: 01/62715 (2001-08-01), None
patent: 01/62751 (2001-08-01), None
patent: 01/64674 (2001-09-01), None
R. I. Souhami and J. Moxham ed.; “Textbook of Medicine” (Oct. 2002, Churchill Livingston, UK) , see Chapter 4, pp. 79-104.
Moreland et al. “Etanercept Therapy in Rheumatoid Arthritis: A Randomized, Controlled Trial”, Ann Intern Med., vol. 130, pp. 478-486 1999.
Elliott et al. “Randomised double-blind comparison of chimeric monoclonal antibody to tumour necrosis factor alpha (cA2) versus placebo in rheumatoid arthritis”, Lancet, vol. 344, pp. 1105-1110 1994.

Affiliated with

Also associated with

Rating

Benzofuran derivative does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Benzofuran derivative, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Benzofuran derivative will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3914807