Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1990-12-07
1992-05-05
Ivy, C. Warren
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514382, 514451, 514459, 514460, 514469, 514470, 548250, 548252, 548253, 548254, 549414, 549467, 549469, 549471, 549292, 549462, A01N 4364, C07D30778
Patent
active
051108259
ABSTRACT:
The compounds of the present invention inhibit HMG-CoA reductase, subsequently suppress the synthesis of cholesterol; and are useful in the treatment of hypercholesterolemia, hyperlipoproteinemia, and atherosclerosis.
REFERENCES:
patent: 4260776 (1981-04-01), Harnisch
patent: 4444784 (1984-04-01), Hoffman et al.
patent: 4816473 (1989-03-01), Dunn
patent: 4927851 (1990-05-01), Damon, II et al.
Derwent Abstract of Japanese Patent Publication No. 59-48418.
Alberts et al., Proc. Natl. Acad. Sci. USA, vol. 77, No. 7, pp. 3957-3961, Jul. 1980.
Kida Shiro
Matsumoto Hiroshi
Ogata Masaru
Shimizu Sumio
Covington Raymond
Ivy C. Warren
Shionogi & Co. Ltd.
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