Benzofuran compounds and their use as antidepressants and...

Details Benzofuran compounds and their use as antidepressants and... Benzofuran compounds and their use as antidepressants and...

2007-08-28

2007-08-28

Saeed, Kamal A. (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C548S454000

Reexamination Certificate

active

10545170

ABSTRACT:
Novel benzofuran derivatives of the formula (I) in which R1, R2, X, Y, Z and m have the meanings indicated in Patent Claim1, they have a strong affinity to the 5-HT1Areceptors. The compounds inhibit serotonin reuptake, exhibit serotonin-agonistic and -antagonistic properties and are suitable as antidepressants, anxiolytics, antipsychotics, neuroleptics and/or antihypertonics

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Raymond et al, The recombinant 5-HT1A receptor: G protein coupling and signalling pathways, Aug. 1999, British Journal of Pharmacology, 127, p. 1751-1764.

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