Benzofuran carboxamides and their therapeutic use

Details Benzofuran carboxamides and their therapeutic use Benzofuran carboxamides and their therapeutic use

1997-05-20

1999-10-26

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514333, 514337, 514342, 514469, 514470, 544124, 546256, 5462697, 5462711, 5462841, 549462, 549466, 549467, 549468, C07D30783, C07D40112, A61K 3134

Patent

active

059729368

ABSTRACT:
Compounds having the formula (i), ##STR1## wherein the groups R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are defined herein. The compounds of the present invention can be utilized to treat disease states capable of being modulated by inhibition of proteins which mediate cellular activity, such as tumor necrosis factor (TNF) and/or phosphodiesterase IV (PDE IV).

REFERENCES:
Damasio, Alzheimer's Disease And Related Dementias, Cecil Textbook of Medicine, 20th Edition, vol. 2, pp. 1992-1996, 1996.
Christensen et al., Chem. Abstract 76:99520, 1972.

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