Benzofuran and dihydrobenzofuran melatonergic agents

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

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549471, 549378, 549387, 548490, C07D30879, C07D31916, C07D49302, C07D20904

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active

058565299

ABSTRACT:
Novel derivatives of benzofuran and dihydrobenzofuran are provided which are useful as melatonergic agents.

REFERENCES:
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patent: 5596019 (1997-01-01), Mattson et al.
Arendt, J. et al. , "Alleviation of Jet Lag by Melatonin: Preliminary Results of Controlled Double Blind Trial", Br. Med. J., 292 , pp. 1170-1172 (May 1986).
Cassone, V. M., et al. , "Dose-Dependent Entrainment of Rat Circadian Rhythms by Daily Injection of Melatonin", J. Biol. Rhythms, 1, (3), pp. 219-229 (1986).
Copinga, S., et al. , "2-Amino-8-methoxytetralins: A Series of Nonindolic Melatonin-like Agents", J. Med. Chem., 36 , pp. 2891-2898 (1993).
Reppert, S. M. et al. , "Cloning and Characterization of a Mammalian Melatonin Receptor That Mediates Reproductive and Circadian Responses", Neuron, 13 , pp. 1177-1185 (Nov. 1994).
Reppert, S. M. et al. , "Molecular Characterization of a Second Melatonin Receptor Expressed in Human Retina and Brain: The Mel.sub.1b Melatonin Receptor", Proc. Natl. Acad. Sci. USA, 92 , pp. 8734-8738 (Sep. 1995).

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