Benzofuran- and benzopyran-carboxamide derivatives

Details Benzofuran- and benzopyran-carboxamide derivatives Benzofuran- and benzopyran-carboxamide derivatives

1984-03-20

1986-10-14

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514466, 514456, 514465, 514316, 514320, 514228, 514229, 514232, 514234, 548525, 548518, 548523, 549404, 549405, 549467, 549462, 546196, 546187, 544151, 544153, 544 79, 544129, 544142, A61K 3134, A61K 3135, C07D40512

Patent

active

046173145

ABSTRACT:
Benzofuran- and benzopyran-carboxamide derivatives of the formula: ##STR1## wherein l is 1 or 2; X is hydrogen atom, amino group or halogen atom; Y is --S(O).sub.m --R.sup.3 wherein R.sup.3 is lower alkyl group and m is 0, 1 or 2, or ##STR2## wherein R.sup.4 and R.sup.5 are the same or different and are each hydrogen atom or lower alkyl group; R.sup.1 is hydrogen atom, lower alkyl group, arylthiomethyl group, halogenomethyl group or ##STR3## wherein R.sup.6 and R.sup.7 are the same or different and are each hydrogen atom or lower alkyl group or R.sup.6 and R.sup.7 together with the adjacent nitrogen atom form a hetrocycle; R.sup.2 is hydrogen atom or lower alkyl group; and Z is ##STR4## wherein p is 2 or 3, R.sup.8 and R.sup.9 are the same or different and are each lower alkyl group or R.sup.8 and R.sup.9 together with the adjacent nitrogen atom form a heterocycle, or ##STR5## wherein q is 0 or 1, n is 1 or 2, R.sup.10 is lower alkyl group, lower alkenyl group, lower alkinyl group, aralkyl group or cycloalkyl group and R.sup.11 is hydrogen atom or lower alkyl group, their physiologically acceptable salts or their optical isomers, and a method of preparing same. These compounds are useful as psychotropic and antipsychotic agents.

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patent: 4525356 (1985-06-01), Itho et al.
Christensen et al.; Chem. Abstracts; vol. 76 (1972), entry 99520y.
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